The term "polypill" describes a pill that contains a combination of several medications commonly used to treat heart disease and high blood pressure. Doctors aren't sure what exact combination of medications should be included in a polypill. It's thought that low doses of each of these medications could be effective:
- Water pills (diuretics)
- Cholesterol-lowering medications (statins)
- Medications to make your heart beat with less force (beta blockers)
- Medications to help keep your blood vessels open (ACE inhibitors)
The polypill is still being studied and isn't available for sale yet in the United States. Who should take the polypill is still being considered. Doctors are trying to see if the polypill should be given as a preventive measure for people who haven't had a heart attack or stroke or as a treatment option for people who have already had a heart attack or stroke.
Apr. 12, 2012
- The Indian Polycap Study (TIPS). Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): A phase II, double-blind, randomised trial. The Lancet. 2009;373:1341.
- Wald DS, et al. The polypill in the primary prevention of cardiovascular disease. Fundamental and Clinical Pharmacology. 2010;24:29.
- PILL Collaborative Group. An international randomised placebo-controlled trial of a four-component combination pill ("polypill") in people with raised cardiovascular risk. PLoS One. 2011;6:e19857.
- Lonn E, et al. The polypill in the prevention of cardiovascular diseases: Key concepts, current status, challenges, and future directions. Circulation. 2010;122:2078.