Guillain-Barre syndrome often begins with tingling and weakness starting in your feet and legs and spreading to your upper body and arms. In about 10 percent of people with the disorder, symptoms begin in the arms or face. As Guillain-Barre syndrome progresses, muscle weakness can evolve into paralysis.
Signs and symptoms of Guillain-Barre syndrome may include:
- Prickling, "pins and needles" sensations in your fingers, toes, ankles or wrists
- Weakness in your legs that spreads to your upper body
- Unsteady walking or inability to walk or climb stairs
- Difficulty with eye or facial movements, including speaking, chewing or swallowing
- Severe pain that may feel achy or cramp-like and may be worse at night
- Difficulty with bladder control or bowel function
- Rapid heart rate
- Low or high blood pressure
- Difficulty breathing
People with Guillain-Barre syndrome usually experience their most significant weakness within two to four weeks after symptoms begin. Recovery usually begins two to four weeks after weakness plateaus.
Once thought to be a single disorder, Guillain-Barre syndrome is now known to occur in several forms. The main types are:
- Acute inflammatory demyelinating polyradiculoneuropathy (AIDP), the most common form in the U.S. The most common sign of AIDP is muscle weakness that starts in the lower part of your body and spreads upward.
- Miller Fisher syndrome (MFS), in which paralysis starts in the eyes. MFS is also associated with unsteady gait. MFS occurs in about 5 percent of people with Guillain-Barre syndrome in the U.S. but is more common in Asia.
- Acute motor axonal neuropathy (AMAN)and acute motor-sensory axonal neuropathy (AMSAN), which are less common in the U.S. but more frequent in China, Japan and Mexico.
When to see a doctor
Call your doctor if you have mild tingling in your toes or fingers that doesn't seem to be spreading or getting worse. Seek emergency medical help if you have any of these severe signs or symptoms:
- Tingling that started in your feet or toes and is now moving up your body
- Tingling or weakness that's spreading rapidly
- Difficulty catching your breath or shortness of breath when lying flat
- Choking on saliva
Guillain-Barre syndrome is a serious condition that requires immediate hospitalization because it can worsen rapidly. The sooner appropriate treatment is started, the better the chance of a good outcome.
June 03, 2014
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed March 10, 2014.
- Vriesendorp FJ. Pathogenesis of Guillain-Barre syndrome in adults. http://www.uptodate.com/home. Accessed March 10, 2014.
- Vriesendorp FJ. Clinical features and diagnosis of Guillain-Barre syndrome in adults. http://www.uptodate.com/home. Accessed March 10, 2014.
- AskMayoExpert. What are the clinical features of Guillain-Barre syndrome (GBS) and how is it diagnosed? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
- Vriesendorp FJ. Treatment and prognosis of Guillain-Barre syndrome in adults. http://www.uptodate.com/home. Accessed March 10, 2014.
- Walling A, et al. Guillain-Barre syndrome. American Family Physician. 2013;87:191.
- Salmon DA, et al. Association between Guillain-Barre syndrome and influenza A (H1N1) 2009 monovalent inactivated vaccines in the USA: A meta-analysis. The Lancet. 2013;381:1461.
- Cruse RP, et al. Overview of Guillain-Barre syndrome in children. http://www.uptodate.com/home. Accessed March 11, 2014.
- Van den Berg B, et al. Mortality in Guillain-Barre syndrome. Neurology. 2013;80:1650.
- Mauermann ML (expert opinion). Mayo Clinic, Rochester, Minn. April 1, 2014.
- Cook, AJ. Decision Support System. Mayo Clinic, Rochester, Minn. March 31, 2014.