Treatments and drugs

By Mayo Clinic Staff

Not everyone who has one seizure will have another one, and because a seizure can be an isolated incident, your doctor may decide to not start treatment until you've had more than one. Treatment usually involves the use of anti-seizure medications.


Many medications are used in the treatment of epilepsy and seizures, such as:

  • Carbamazepine (Carbatrol,Tegretol, others)
  • Phenytoin (Dilantin, Phenytek)
  • Valproic acid (Depakene)
  • Oxcarbazepine (Trileptal)
  • Lamotrigine (Lamictal)
  • Gabapentin (Gralise, Neurontin)
  • Topiramate (Topamax)
  • Phenobarbital
  • Zonisamide (Zonegran)
  • Levetiracetam (Keppra)
  • Tiagabine (Gabitril)
  • Pregabalin (Lyrica)
  • Felbamate (Felbatol)
  • Ethosuximide (Zarontin)
  • Lorazepam (Ativan)
  • Clonazepam (Klonopin)
  • Clobazam (Onfi)
  • Rufinamide (Banzel)
  • Perampanel (Fycompa)

Finding the right medication and dosage can be challenging. Your doctor likely will first prescribe a single drug at a relatively low dosage, and then increase the dosage gradually until your seizures are well-controlled.

Many people with epilepsy are able to prevent seizures by taking only one drug, but others require more than one. If you've tried two or more single-drug regimens without success, your doctor may recommend trying a combination of two drugs.

To achieve the best seizure control possible, take medications exactly as prescribed. Always call your doctor before adding other prescription medications, over-the-counter drugs or herbal remedies.

And never stop taking your medication without talking to your doctor.

Mild side effects of anti-seizure medications can include:

  • Fatigue
  • Dizziness
  • Weight gain

More-troubling side effects that need to be brought to your doctor's attention immediately include:

  • Mood disruption
  • Skin rashes
  • Loss of coordination
  • Speech problems
  • Extreme fatigue

In addition, the drug Lamictal has been linked to an increased risk of aseptic meningitis, an inflammation of the protective membranes that cover the brain and spinal cord that's similar to bacterial meningitis.

Pregnancy and seizures

Women who've had previous seizures usually are able to have healthy pregnancies. Birth defects related to certain medications can sometimes occur.

In particular, valproic acid has been associated with cognitive deficits and neural tube defects, such as spina bifida. The American Academy of Neurology recommends that women avoid using valproic acid during pregnancy because of risks to the baby.

Discuss these risks with your doctor. Because of the risk of birth defects, and because pregnancy can alter medication levels, preconception planning is particularly important for women who've had seizures.

In some cases, it may be appropriate to change the dose of seizure medication before or during pregnancy. Medications may be switched in rare cases.

Contraception and anti-seizure medications

It's also important to know that some anti-seizure medications can alter the effectiveness of oral contraceptive (birth control) medication. If contraception is a high priority, check with your doctor to evaluate whether your medication interacts with your oral contraceptive, and if other forms of contraception need to be considered.

June 10, 2014