GERD is caused by frequent acid reflux — the backup of stomach acid or bile into the esophagus.
When you swallow, the lower esophageal sphincter — a circular band of muscle around the bottom part of your esophagus — relaxes to allow food and liquid to flow down into your stomach. Then it closes again.
However, if this valve relaxes abnormally or weakens, stomach acid can flow back up into your esophagus, causing frequent heartburn. Sometimes this can disrupt your daily life.
This constant backwash of acid can irritate the lining of your esophagus, causing it to become inflamed (esophagitis). Over time, the inflammation can wear away the esophageal lining, causing complications such as bleeding, esophageal narrowing or Barrett's esophagus (a precancerous condition).
Jul. 31, 2014
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed Jan. 2, 2014.
- Kahrilas PJ. Clinical manifestations and diagnosis of gastroesophageal reflux in adults. http://www.uptodate.com/home. Accessed Jan. 1, 2014.
- Kahrilas PJ. Medical management of gastroesophageal reflux disease in adults. http://www.uptodate.com/home. Accessed Jan. 1, 2014.
- Schwaitzberg SD. Surgical management of gastroesophageal reflux in adults. http://www.uptodate.com/home. Jan. 5, 2014.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Jan. 2, 2014.
- Bope ET, et al. Conn's Current Therapy. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed Jan. 2, 2014.
- Kahrilas PJ. Complications of gastroesophageal reflux in adults. http://www.uptodate.com/home. Accessed Jan. 5, 2014.
- Katz PO, et al. Guidelines for the diagnosis and management of gastroesophageal reflux disease. American Journal of Gastroenterology. 2013;108:308.
- AskMayoExpert. Gastroesophageal reflux disease. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
- Weight management. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/public/heart/obesity/lose_wt/recommen.htm. Accessed Jan. 2, 2014.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. April 24, 2011.
- Golden AK. Decision Support System. Mayo Clinic, Rochester, Minn. Dec. 23, 2013.
- Fass R. Alternative therapeutic approaches to chronic proton pump inhibitor. Clinical Gastroenterology and Hepatology. 2012;10:338.
- Patrick L. Gastroesophageal reflux disease (GERD): A review of conventional and alternative treatments. Alternative Medicine Review. 2011;16:116.
- Safe use of complementary health products and practices. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/safety. Accessed Jan. 5, 2014.
- Lipham JC, et al. The LINX® reflux management system: Confirmed safety and efficacy now at 4 years. Surgical Endoscopy. 2012;26:2944.
- U.S. News best hospitals 2013-2014. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings/gastroenterology-and-gi-surgery. Accessed Jan. 2, 2014.
- Alexander JA (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 12, 2014.
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