Signs and symptoms of gastroparesis include:
- A feeling of fullness after eating just a few bites
- Vomiting undigested food eaten a few hours earlier
- Acid reflux
- Abdominal bloating
- Abdominal pain
- Changes in blood sugar levels
- Lack of appetite
- Weight loss and malnutrition
Many people with gastroparesis don't have any noticeable signs and symptoms.
When to see a doctor
Make an appointment with your doctor if you have any signs or symptoms that worry you.
It's not always clear what leads to gastroparesis. But in many cases, gastroparesis is believed to be caused by damage to a nerve that controls the stomach muscles (vagus nerve).
The vagus nerve helps manage the complex processes in your digestive tract, including signaling the muscles in your stomach to contract and push food into the small intestine. A damaged vagus nerve can't send signals normally to your stomach muscles. This may cause food to remain in your stomach longer, rather than move normally into your small intestine to be digested.
The vagus nerve can be damaged by diseases, such as diabetes, or by surgery to the stomach or small intestine.
Factors that can increase your risk of gastroparesis:
- Abdominal or esophageal surgery
- Infection, usually a virus
- Certain medications that slow the rate of stomach emptying, such as narcotic pain medications
- Scleroderma (a connective tissue disease)
- Nervous system diseases, such as Parkinson's disease or multiple sclerosis
- Hypothyroidism (low thyroid)
Women are more likely to develop gastroparesis than are men.
Gastroparesis can cause several complications, such as:
- Severe dehydration. Ongoing vomiting can cause dehydration.
- Malnutrition. Poor appetite can mean you don't take in enough calories, or you may be unable to absorb enough nutrients due to vomiting.
- Undigested food that hardens and remains in your stomach. Undigested food in your stomach can harden into a solid mass called a bezoar. Bezoars can cause nausea and vomiting and may be life-threatening if they prevent food from passing into your small intestine.
- Unpredictable blood sugar changes. Although gastroparesis doesn't cause diabetes, frequent changes in the rate and amount of food passing into the small bowel can cause erratic changes in blood sugar levels. These variations in blood sugar make diabetes worse. In turn, poor control of blood sugar levels makes gastroparesis worse.
- Decreased quality of life. An acute flare-up of symptoms can make it difficult to work and keep up with other responsibilities.
June 16, 2017
- Feldman M, et al. Gastric neuromuscular function and neuromuscular disorders. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed Nov. 7, 2016.
- Gastroparesis. The National Digestive Diseases Information Clearinghouse. https://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/gastroparesis/Pages/facts.aspx. Accessed Nov. 7, 2016.
- AskMayoExpert. Gastroparesis. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016.
- Camilleri M. lGastroparesis: Etiology, clinical manifestations, and diagnosis. http://www.uptodate.com/home. Accessed Nov. 6, 2016.
- Bharucha AE. Epidemiology and natural history of gastroparesis. Gastroenterology Clinics of North America. 2015;44:9.
- Clinical guideline: Management of gastroparesis. Bethesda, Md.: American College of Gastroenterology. http://gi.org/guideline/management-of-gastroparesis/. Accessed Nov. 6, 2016.
- Bouras EP, et al. Gastroparesis: From concepts to management. Nutrition in Clinical Practice. 2013;28:437.
- Parrish CR. Nutritional considerations in the patient with gastroparesis. Gastroenterology Clinics of North America. 2015;44:83.
- Camilleri M. Treatment of gastroparesis. http://www.uptodate.com/home. Accessed Nov. 6, 2016.
- Lembo A, et al. Relamorelin reduces vomiting frequency and severity and accelerates gastric emptying in adults with diabetic gastroparesis. Gastroenterology. 2016;151:87.
- Camilleri M. Novel diet, drugs, and gastric interventions for gastroparesis. Clinical Gastroenterology and Hepatology. 2016;14:1072.
- Hasler WL. Electrical stimulation for gastroparesis. http://www.uptodate.com/home. Accessed Nov. 6, 2016.
- Stein BJ, et al. Gastroparesis: A review of current diagnosis and treatment options. Journal of Clinical Gastroenterology. 2015;49:550.
- Parkman HP. Idiopathic gastroenterology. Gastroenterology Clinics of North America. 2015;44:59.
- Levinthal DJ, et al. Systematic review and meta-analysis: Gastric electrical stimulation for gastroparesis. Autonomic Neuroscience: Basic and Clinical. In press. Accessed Nov. 6, 2016.
- Lal Nikhil, et al. Gastric electrical stimulation with the Enterra System: A systematic review. Gastroenterology Research and Practice. 2015;2015:1.
- Lee LA, et al. Complementary and alternative medicine for gastroparesis. Gastroenterology Clinics of North America. 2015;44:137.
- Pasricha PJ, et al.Outcomes and factors associated with reduced symptoms in patients with gastroparesis. Gastroenterology. 2015;149:1762.
- Brown A. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Nov. 11, 2016.