What gallbladder cancer treatment options are available to you will depend on the stage of your cancer, your overall health and your preferences.
The initial goal of treatment is to remove the gallbladder cancer, but when that isn't possible, other therapies may help control the spread of the disease and keep you as comfortable as possible.
Surgery for early-stage gallbladder cancer
Surgery may be an option if you have an early-stage gallbladder cancer. Options include:
- Surgery to remove the gallbladder. Early gallbladder cancer that is confined to the gallbladder is treated with an operation to remove the gallbladder (cholecystectomy).
- Surgery to remove the gallbladder and a portion of the liver. Gallbladder cancer that extends beyond the gallbladder and into the liver is sometimes treated with surgery to remove the gallbladder, as well as portions of the liver and bile ducts that surround the gallbladder.
It's not clear whether additional treatments after successful surgery can increase the chances that your gallbladder cancer won't return. Some studies have found this to be the case, so in some instances, your doctor may recommend chemotherapy, radiation therapy or a combination of both after surgery.
Discuss the potential benefits and risks of additional treatment with your doctor to determine what's right for you.
Treatments for late-stage gallbladder cancer
Surgery can't cure gallbladder cancer that has spread to other areas of the body. Instead, doctors use treatments that may relieve signs and symptoms of cancer and make you as comfortable as possible.
Options may include:
- Chemotherapy. Chemotherapy is a drug treatment that uses chemicals to kill cancer cells.
- Radiation therapy. Radiation uses high-powered beams of energy, such as X-rays and protons, to kill cancer cells.
- Clinical trials. Clinical trials are studies testing experimental or new medications to treat gallbladder cancer. Talk to your doctor to see whether you're eligible to participate in a clinical trial.
Procedures to relieve blocked bile ducts
Advanced gallbladder cancer can cause blockages in the bile ducts, causing further complications. Procedures to relieve blockages may help. For instance, surgeons can place a hollow metal tube (stent) in a duct to hold it open or surgically reroute bile ducts around the blockage (biliary bypass).
July 28, 2017
- Gallbladder cancer treatment (PDQ). National Cancer Institute. https://www.cancer.gov/types/gallbladder/patient/gallbladder-treatment-pdq. Accessed June 19, 2017.
- Niederhuber JE, et al., eds. Liver and bile duct cancer. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. https://www.clinicalkey.com. Accessed June 19, 2017.
- Feldman M, et al., eds. Tumors of the bile ducts, gallbladder and ampulla. In: Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. https://www.clinicalkey.com. Accessed June 19, 2017.
- Hepatobiliary cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed June 19, 2017.
- Warner KJ. Allscripts EPSi. Mayo Clinic, Rochester, Minn. April 10, 2017.
- Amin MB, et al., eds. Gallbladder. In: AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer; 2017.