SymptomsBy Mayo Clinic Staff
As the disease progresses, Fuchs' dystrophy symptoms usually affect both eyes and may include:
- Glare, which is an early symptom and reduces contrast perception or affects vision in low light.
- Blurred vision, which occurs in the morning after awakening and gradually improves during the day. As the disease progresses, vision can take longer to improve or may not improve.
- Distorted vision, sensitivity to light, difficulty seeing at night and seeing halos around light
- Painful, tiny blisters on the surface of your cornea
- A cornea that looks cloudy or hazy
When your ophthalmologist examines your cornea, he or she looks for:
- Irregular bumps on the back surface of the cornea (guttae)
- Corneal swelling
- Corneal haze
- Thickening of the cornea, measured by a special instrument (typically an ultrasound)
When to see a doctor
If you experience some of these signs and symptoms, and especially if they get worse over time, see an eye specialist (ophthalmologist). If symptoms develop suddenly, call an ophthalmologist for an urgent appointment. Other eye conditions that cause the same symptoms as Fuchs' dystrophy also require prompt treatment.
July 22, 2014
- Facts about the cornea and corneal disease. National Eye Institute. http://www.nei.nih.gov/health/cornealdisease. Accessed Feb. 7, 2014.
- What is Fuchs' dystrophy? American Academy of Ophthalmology. http://www.geteyesmart.org/eyesmart/diseases/fuchs-dystrophy.cfm. Accessed Feb. 7, 2014.
- Patel SV, et al. Anterior corneal aberrations after Descemet's stripping endothelial keratoplasty for Fuchs' endothelial dystrophy. Ophthalmology. 2012;119:1522.
- Gipson IK. Age-related changes and diseases of the ocular surface and cornea. Investigative ophthalmology and visual science. 2013;54:ORSF48.
- Hamill CE, et al. Fuchs endothelial cornea dystrophy: A review of the genetics behind disease development. Seminars in Ophthalmology. 2013;28:281.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. Feb. 10, 2014.
- Wieben ED, et al. A common trinucleotide repeat expansion within the transcription factor 4 (TCF4, E2-2) gene predicts Fuchs corneal dystrophy. PLoS One. 2012;7:e49083. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049083. Accessed Feb. 13, 2014.
- What is a comprehensive dilated eye exam? National Eye Institute. http://www.nei.nih.gov/healthyeyes/eyeexam.asp. Accessed Feb. 24, 2014.
- The Wills Eye Manual: Office and Emergency Room Diagnosis and Treatment of Eye Disease Gerstenblith AT, et al., eds. Disease. 6th ed. Philadelphia, Pa.: Wolters Kluwer Health Lippincott Williams & Wilkins; 2012. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=booktext&D=books3&AN=01626623/6th_Edition/2&XPATH=/OVIDBOOK%5b1%5d/METADATA%5b1%5d/TBY%5b1%5d/EDITORS%5b1%5d. Accessed Feb. 24, 2014.
- Robertson DM (expert opinion). Mayo Clinic, Rochester, Minn. March 5, 2014.
- Patel SV. Graft survival and endothelial outcomes in the new era of endothelial keratoplasty. Experimental Eye Research. 2012; 95:40.
- Patel SV (expert opinion). Mayo Clinic, Rochester, Minn. May 20, 2014.
- Baratz KH, et al. E2-2 protein and Fuchs's corneal dystrophy. New England Journal of Medicine. 2010;363:1016.