- Experience. Mayo Clinic treats more than 400 people each year who have focal segmental glomerulosclerosis.
- Expertise. The large number of kidney specialists (nephrologists) at Mayo Clinic allows doctors to subspecialize in specific aspects of kidney medicine, including glomerular diseases such as FSGS.
- Teamwork. Kidney specialists work together with transplant specialists and other experts to develop the best treatment plan for you.
- New ideas. Mayo is active in research to better understand this condition and to test new therapies for FSGS through the Mayo Nephrology Collaborative Group.You may have the opportunity to participate in clinical trials of experimental treatments.
- Coordinated care. Mayo doctors work closely with your local doctor to coordinate treatment and follow-up care.
In the early stages, you may have no symptoms of focal segmental glomerulosclerosis (FSGS). As the disease progresses, signs of nephrotic syndrome will appear. Nephrotic syndrome is a disease that causes your body to excrete too much protein in the urine. Signs of this disease include a foamy appearance to your urine, high blood pressure and swelling in your face, hands or legs. Primary FSGS that is unresponsive to treatment will often progress over time to end-stage kidney disease. When your kidneys fail, you will die without either dialysis or a kidney transplant.
There are a number of types of FSGS:
- Primary FSGS. A significant number of people diagnosed with FSGS have no known cause for their condition. This is called primary (idiopathic) FSGS.
- Secondary FSGS. This condition is brought on by factors such as obesity, the use of anabolic steroids or other types of kidney diseases. Controlling the primary cause often improves kidney function.
- Genetic (familial) FSGS. This rare form of FSGS is caused by genetic mutations. It is suspected when several members of a family show signs of FSGS. Familial FSGS can also occur when neither parent has the disease, but each carries one copy of an abnormal gene that can be passed on to the next generation. Therefore, the absence of disease in other family members does not exclude the possibility that the disease may be inherited.
Mayo Clinic in Rochester, Minn., ranks No. 1 for kidney disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Scottsdale, Ariz., and Mayo Clinic in Jacksonville, Fla., are ranked high performing for kidney disorders by U.S. News & World Report.
Mayo Clinic: Answers you can trust
At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.
Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.
Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.
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Nov. 19, 2012