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Amyloid pathology of Alzheimer's disease
The Department of Neuroscience at Mayo Clinic is at the forefront of research focused on neurodegeneration and age-related disorders.
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Synaptic biology
Mayo Clinic's Department of Neuroscience focuses on basic and translational research to address the unmet needs of patients with neurological disorders.
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Patient-derived cerebral organoid
Mayo Clinic researchers develop innovative approaches and models to determine the molecular causes of brain disorders and how to combat them.
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Tau pathology of Alzheimer's disease
Mayo Clinic investigators utilize the unparalleled insights offered by the human brain to guide research directions.
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Mouse model of disease
Neuroscience researchers adopt a team-based approach to avail the wide-ranging expertise of basic scientists, geneticists, pathologists, clinicians and bioinformaticians.
Overview
The Department of Neuroscience at Mayo Clinic's campus in Florida is at the forefront of a new era of research in aging, neurodegeneration and neurotherapeutics. The department is committed to understanding Alzheimer's disease and related dementias, movement disorders such as Parkinson's disease, amyotrophic lateral sclerosis and ataxias, and cerebrovascular diseases. With a vision of translating discovery to addressing the unmet needs of patients, it also emphasizes research geared toward identifying and developing therapies to treat and prevent these devastating disorders. A combination of world-renowned experts, unique resources and productive collaborations among basic scientists, geneticists, neurologists and neuropathologists makes the Department of Neuroscience a leader in its field.
Through the use of highly innovative approaches and cutting-edge technologies, paired with the creation of sophisticated preclinical models, investigators in the Department of Neuroscience seek to decipher the underlying causes of neurological disorders, develop new methods to improve diagnostic and prognostic assessments, and discover novel therapeutic strategies. These endeavors greatly benefit from the more than 9,300 specimens available through Mayo Clinic's brain bank in Florida, from human cells banked by the Center for Regenerative Biotherapeutics to generate robust disease models such as organoids, and from close collaborations with the Department of Neurology and the Department of Neurosurgery, which facilitate human studies and the collection of biospecimens. These resources, along with the Alzheimer's Disease Research Center that promotes research and education about healthy brain aging, mild cognitive impairment, Alzheimer's disease and related dementia disorders, are invaluable.
The department, which serves as a crucial training ground for graduate students and postdoctoral fellows, also houses the Neuroscience Track within the Ph.D. Program at the Mayo Clinic Graduate School of Biomedical Sciences and offers a multitude of training opportunities for students at various stages in their education.