Factor V Leiden can be associated with a variety of serious and potentially serious clotting complications, including:

  • Pregnancy complications. Although most women with factor V Leiden have normal pregnancies, the mutation has been linked with an increased risk of miscarriage and possibly other complications during pregnancy, including pregnancy-induced high blood pressure (preeclampsia), slow fetal growth and early separation of the placenta from the uterine wall (placental abruption). If you're a woman with factor V Leiden and you get pregnant, be sure your doctor monitors you carefully throughout your pregnancy.
  • Deep vein thrombosis (DVT). People with factor V Leiden have an increased risk of developing DVT compared with someone without the mutation, though the overall risk of developing DVT is still low.
  • Pulmonary embolism. DVT puts you at risk of a clot breaking off and traveling to your lungs or, rarely, your brain. A pulmonary embolism can be fatal, so it's important to watch for signs and symptoms of a pulmonary embolism, such as shortness of breath or chest pain, and to seek prompt medical attention.
Sep. 06, 2012