Sept. 13, 2014
Below are current clinical trials.7 studies in Esophagitis
(open studies only).
Filter this list of studies by location, status and more.
This is a multicenter, double- blind extension study of Oral Budesonide Suspension (OBS) in adults and adolescents (11 to 55 years of age, inclusive) with Eosinophilic Esophagitis (EoE) who have completed participation in the SHP621-301 induction study (NCT02605837). The primary objective is to evaluate the maintenance of efficacy of OBS over 36 weeks. Maintenance of efficacy will be measured by the peak eosinophilic count and Dysphagia Symptom Questionnaire (DSQ) score.
The purpose of this study is to perform RNA (genetic) sequencing on biopsies taken from the esophagus of adult patients who have active eosinophilic esophagitis, and look for potential therapeutic targets.
Part 1 of the study will retrospectively compare the role of mast cells in children versus adult EoE patients based on the peak mast cell density. Children with EoE have been shown to have more mast cell mediator-type of symptoms (vomiting, abdominal pain) than that of adults (solid food dysphagia). We hypothesize a greater peak mast cell density in the esophageal biopsies of children than in adults with EoE. The group (children or adults) which show greater peak mast cell density will be the group for Part 2 of the study.
Part 2 of the study will prospectively compare the role of mast cells in EoE patients (either children or adults, based on Part 1 study). Histamine mediators, including serum tryptase and 24 hour urine beta-prostaglandin, N-methylhistamine, and leukotriene E4, will be obtained close to the time of obtaining esophageal biopsies. Further analysis will determine if there is a correlation between histamine release and peak mast cell density in the esophageal biopsies.
Are we able to use the EPO staining technique using the sponge ?
The purpose of this study is to determine if patients treated with long term maintenance medical therapies have a lowered risk of needing subsequent esophageal dilations, and to determine if there are characteristics (demographic, symptoms at initial dilation, biopsy characteristics) that increase risk of or are associated with needing subsequent dilation therapy.
The purpose of this study is to investigate the use of noninvasive ultrasound shear wave elastography and ultrasound blood vessel imaging to evaluate eosinophilic esophagitis.
Whether the cytosponge will be a useful non-invasive tool in evaluating patients with eosinophilic esophagitis?
- Bleeding in the digestive tract. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/DDISEASES/pubs/bleeding/. Accessed July 11, 2014.
- Heartburn, gastroesophageal reflux (GER), and gastroesophageal reflux disease (GERD). National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/gerd/index.aspx. Accessed July 10, 2014.
- Castell DO. Medication-induced esophagitis. http://www.uptodate.com/home. Accessed July 10, 2014.
- Bope ET, et al. Conn's Current Therapy. Philadelphia, Pa.: Saunders Elsevier; 2014. http://www.clinicalkey.com. Accessed Jan. 2, 2014.
- Ek WE, et al. Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux. Journal of the National Cancer Institute. 2013;105:1711.
- Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.clinicalkey.com. Accessed July 11, 2014.
- Almashat SJ, et al. Non-reflux esophagitis: A review of inflammatory diseases of the esophagus exclusive of reflux esophagitis. Seminars in Diagnostic Pathology. 2014;31:89.
- Kauffman CA. Clinical manifestations of oropharyngeal and esophageal candidiasis. http://www.uptodate.com/home. Accessed July 10, 2014.
- Goldman L, et al. Goldman's Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed July 16, 2014.
- Medical Edge from Mayo Clinic. Hard to Swallow — EOE. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014. http://www.mayoclinic.org/medical-edge/. Accessed March 9, 2014.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. April 24, 2011.
- Safe use of complementary health products and practices. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/safety. Accessed Jan. 5, 2014.
- Best hospitals. U.S. News & World Report. http://health.usnews.com/best-hospitals/area/mn/mayo-clinic-661MAYO. Accessed Sept. 2, 2014.
- Geagea A, et al. Scope of drug-induced, infectious and allergic esophageal injury. Current Opinion in Gastroenterology. 2008;24:496.
- Dellon ES, et al. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). The American Journal of Gastroenterology. 2013;108:679.
- Katz PO, et al. Guidelines for the diagnosis and management of gastroesophageal reflux disease. American Journal of Gastroenterology. 2013;108:308.
- Eosinophilic esophagitis. American Academy of Asthma, Allergy & Immunology. http://www.aaaai.org/conditions-and-treatments/related-conditions/eosinophilic-esophagitis.aspx. Accessed July 17, 2014.
- Estores D, et al. Barrett esophagus: Epidemiology, pathogenesis, diagnosis, and management. Current Problems in Surgery. 2013;50:192.
- Kahrilas PJ. Medical management of gastroesophageal reflux disease in adults. http://www.uptodate.com/home. Accessed Jan. 1, 2014.
- Tomizawa Y, et al. Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus: A pilot ex-vivo study. World Journal of Gastroenterology. 2013;19:8652.
- Lipham JC, et al. The LINX® reflux management system: Confirmed safety and efficacy now at 4 years. Surgical Endoscopy. 2012;26:2944.
- Ravi K (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 15, 2014.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Jan. 2, 2014.
- Patrick L. Gastroesophageal reflux disease (GERD): A review of conventional and alternative treatments. Alternative Medicine Review. 2011;16:116.