Below are current clinical trials.21 studies in Epilepsy
(open studies only).
Filter this list of studies by location, status and more.
The study is designed to evaluate the safety and efficacy of the Visualase MRI-guided laser ablation system for mesial temporal epilepsy (MTLE).
This is a randomized, double-blind, placebo-controlled trial, designed to evaluate the effectiveness and safety of SAGE-547 administered as a continuous intravenous infusion to patients in very resistant status epilepticus.
The purpose of this study is to determine how frequently primary headache syndromes occur in a population of epilepsy patients admitted to an epilepsy monitoring unit.
The purpose if this study to combine state of the art cerebral signal processing techniques and localization methods with intracranial electrode recordings to investigate the interaction of local hippocampal and neocortical networks with distributed brain activity.
The patient has failed all other available agents and has intractable epilepsy due to Dravet Syndrome. Stiripentol is highly efficacious in Dravet Syndrome. The overall goals of therapy with Stiripentol are primarily to significantly reduce the frequency and severity of seizures.
The purpose of this study is to evaluate the safety of giving repeat doses of NRL-1 when it is used to treat people who have epilepsy.
The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these changes to the heart and blood vessels. This research study measures those differences which may help identify new markers to help predict those patients at greatest risk in the future.
The purpose of this study is to assess the thalamus area of the brain using stereotactic electroencephalography (an EEG with deep electrode placement inside the brain) to better understand its role in the starting and spreading of epileptic seizure activity.
Jacksonville, Fla., Scottsdale/Phoenix, Ariz., Rochester, Minn.
The purpose of this study is to find out if home-recorded Smartphone videos can be used to accurately diagnose epilepsy in patients seeking evaluation for seizures. The idea is to compare the home-recorded video to video-EEG monitoring, which is the current gold-standard for diagnosis.
This study is designed to evaluate the high-frequency range deep brain oscillations (HFO) as pathologic markers in patients undergoing deep brain stimulation for epilepsy or Parkinson disease. Newly developed technology allows for the chronic recording of these brain signals at the same time as clinical stimulation is occuring. We will learn both whether these HFO correlate with disease activity and whether the HFO change in response to ongoing stimulation (potentially giving insight into the underlying mechanism of action of DBS). Study participants will undergo DBS in the same way as is usually done but will receive this newer battery with ability to record brain signals.
Nov. 06, 2015
- Seizures and epilepsy: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm. Accessed Sept. 25, 2014.
- Schachter SC. Evaluation of the first seizure in adults. http://www.uptodate.com/home. Accessed Sept. 26, 2014.
- Is an emergency room visit needed? Epilepsy Foundation. http://www.epilepsyfoundation.org/aboutepilepsy/firstaid/is-an-emergency-room-visit-needed.cfm. Accessed Jan. 28, 2013.
- Injuries from seizures. Epilepsy Foundation. http://www.epilepsyfoundation.org/aboutepilepsy/healthrisks/injuriesfromseizures.cfm. Accessed Jan. 28, 2013.
- Fact sheet on seizure-related causes of death and preventative measures. Epilepsy Foundation. http://www.epilepsyfoundation.org/resources/newsroom/pressreleases/Fact-Sheet-on-Seizure-Related-Causes-of-Death-and-Preventative-Measures.cfm. Accessed Jan. 28, 2013.
- Schachter SC. Sudden unexpected death in epilepsy. http://www.uptodate.com/home. Accessed Jan. 18, 2013.
- Frequently asked questions. Epilepsy Foundation. http://www.epilepsyfoundation.org/aboutepilepsy/faq.cfm. Accessed Jan. 28, 2013.
- Neurological diagnostic tests and procedures. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/misc/diagnostic_tests.htm. Accessed Jan. 28, 2013.
- Hirsch LJ, et al. Neuroimaging in the evaluation of seizures and epilepsy. http://www.uptodate.com/home. Accessed Jan. 18, 2013.
- Karceski S. Initial treatment of epilepsy in adults. http://www.uptodate.com/home. Accessed Sept. 26, 2014.
- Schachter SC. Overview of the management of epilepsy in adults. http://www.uptodate.com/home. Accessed Sept. 26, 2014.
- Wetjen NM, et al. Subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging in evaluating the need for repeated epilepsy surgery. Journal of Neurosurgery. 2006;105:71.
- Noe KH. Seizures: Diagnosis and management in the outpatient setting. Seminars in Neurology. 2011;31:54.
- Barbara Woodward Lips Patient Education Center. Surgical treatment for seizures. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2004.
- O'Brien TJ, et al. Subtraction SPECT co-registered to MRI improves postictal SPECT localization of seizure foci. Neurology. 1999;52:137.
- Lyons MK. Deep brain stimulation: Current and future clinical applications. Mayo Clinic Proceedings. 2011;86:662.
- U.S. News best hospitals 2012-2013. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings. Accessed Jan. 25, 2013.
- First responders. Epilepsy Foundation. http://www.epilepsyfoundation.org/livingwithepilepsy/firstresponders/. Accessed Jan. 31, 2013.
- Staying healthy. Epilepsy Foundation. http://www.epilepsyfoundation.org/livingwithepilepsy/healthandwellness/stayinghealthy/index.cfm. Accessed Jan. 31, 2013.
- Transportation. Epilepsy Foundation. http://www.epilepsyfoundation.org/livingwithepilepsy/parentsandcaregivers/caregivers/transportation.cfm. Accessed Jan. 31, 2013.
- First aid. Epilepsy Foundation. http://www.epilepsyfoundation.org/aboutepilepsy/firstaid/index.cfm. Accessed Jan. 31, 2013.
- Finding employment. Epilepsy Foundation. http://www.epilepsyfoundation.org/livingwithepilepsy/employmenttopics/findingemployment.cfm. Accessed Feb. 4, 2013.
- Romanelli P, et al. Non-resective surgery and radiosurgery for treatment of drug-resistant epilepsy. Epilepsy Research. 2012;99:193.
- Worrell GA (expert opinion). Mayo Clinic, Rochester, Minn. April 29, 2013.
- Willie, J. et al. Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy. Neurosurgery. 2014;74:58.
- Curing the epilepsies: The promise of research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/epilepsy/epilepsy_research.htm#Section2_2 Accessed Sept. 26, 2014.
- Chatman M, et al. Stereotactic-guided laser ablation of epileptogenic abnormalities in intractable focal epilepsy: Preliminary results. Neurology. 2013;80:P04.196. http://www.neurology.org/cgi/content/meeting_abstract/80/1_MeetingAbstracts/P04.196. Accessed Sept. 26, 2014.
- Thurman DJ, et al. Sudden unexpected death in epilepsy: Assessing the public health burden. Epilepsia. In press. Accessed Sept. 26, 2014.
- Epilepsy across the spectrum: Promoting health and understanding. Institute of Medicine. http://www.iom.edu/~/media/Files/Report%20Files/2012/Epilepsy/epilepsy_rb.pdf. Accessed Sept. 26, 2014
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