Treatment options for eosinophilic gastrointestinal disorders
Eosinophilic gastrointestinal disorders (EGIDs) are characterized by higher than normal amounts of a type of white blood cell (eosinophils) in organs that make up the digestive system.
Several types of eosinophilic gastrointestinal disorders exist, including eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis and eosinophilic colitis. Each of the four types of these disorders results in inflammation in and injury to the area of the digestive system it affects — the esophagus, the stomach, the stomach and small intestine, or the large intestine, respectively.
Acid reducers, dietary therapy and steroids are recommended treatments for eosinophilic esophagitis, the most common form of eosinophilic gastrointestinal disorder.
No standard treatments exist for eosinophilic gastritis, eosinophilic gastroenteritis and eosinophilic colitis, although dietary therapy and steroids may be prescribed for these conditions.
Medications that reduce acid production in the stomach (proton pump inhibitors) will often be prescribed as the initial treatment for eosinophilic gastrointestinal disorders.
June 17, 2014
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- Dellon ES, et al. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis. The American Journal of Gastroenterology. 2013;108:679.
- Treatment of EGIDs. American Partnership for Eosinophilic Disorders. http://www.apfed.org/drupal/drupal/Treatment of EGIDs. Accessed May 21, 2014.
- Alfadda AA, et al. Eosinophilic colitis: An update on pathophysiology and treatment. British Medical Bulletin 2011;100:59.
- What are EGIDs? American Partnership for Eosinophilic Disorders. http://www.apfed.org/drupal/drupal/what_are_egids. Accessed May 21, 2014.