Mayo Clinic is a leader in eosinophilic esophagitis research and actively researches eosinophilic disorders. Mayo researchers have tested the effects of many medications on treatment, including:
- Asthma medications
- Acid-blocking medications
Clinical trials are underway to study long-term management and remission of eosinophilic esophagitis. These include:
- Diagnosis of PPI-REE
- Drug treatment using montelukast (Singulair)
- Oral nitrous oxide levels in patients with eosinophilic esophagitis
Mayo Clinic researchers are also studying the use of a device called the cytosponge as a replacement for endoscopy to monitor ongoing treatment for eosinophilic esophagitis. The cytosponge is a small sponge inside a capsule attached to a string. You swallow the capsule, which dissolves; the doctor then pulls out the sponge, scraping cells off your esophagus. It's quick, inexpensive, minimally invasive and does not require anesthesia.
The Allergic Diseases Research Laboratory at Mayo Clinic in Minnesota investigates the mechanisms of common airway and skin diseases. The lab focuses on and studies types of immune (white blood) cells, especially eosinophils. Laboratories in the areas of clinical immunology and immunotherapeutics, immunology, and gastroenterology and hepatology also are involved in research on eosinophilic disorders.
See a list of publications by Mayo Clinic doctors about eosinophilic esophagitis on PubMed, a service of the National Library of Medicine.
June 19, 2014
- Sami R. Achem, M.D.
- Jeffrey A. Alexander, M.D.
- Amindra S. Arora, M.B., B.Chir.
- Joseph H. Butterfield, M.D.
- Kenneth R. Devault, M.D.
- David E. Fleischer, M.D.
- Dawn L. Francis, M.D.
- David A. Katzka, M.D.
- Hirohito Kita, M.D.
- Shabana F. Pasha, M.D.
- Michael F. Picco, M.D.
- Catherine R. Weiler, M.D., Ph.D.
- Bonus PAL, et al. Pathogenesis, clinical manifestations, and diagnosis of eosinophilic esophagitis. http://www.uptodate.com/home. Accessed Jan. 28, 2014.
- Dellon ES, et al. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). The American Journal of Gastroenterology. 2013;108:679.
- Feldman M., et al. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.clinicalkey.com.Accessed Jan. 18, 2014.
- Liacouras CA, et al. Eosinophilic esophagitis: Updated consensus recommendations for children and adults. Journal of Allergy and Clinical Immunology. 2011;128:3.
- Fell JME. Recognition, assessment and management of eosinophilic oesophagitis. Archives of Disease in Childhood. 2013;98:702.
- Picco MF (expert opinion). Mayo Clinic, Rochester, Minn. April 6, 2014.
- Gorospe EC, et al. New diagnostic and therapeutic frontiers in eosinophilic esophagitis. Minerva gastroenterologica e dietologica. 2013;59:59.
- Medical Edge from Mayo Clinic. Hard to Swallow — EOE. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014. http://www.mayoclinic.org/medical-edge/. Accessed March 9, 2014.
- Molina-Infante J, et al. Review article: Proton pump inhibitor therapy for suspected eosinophilic oesophagitis. Alimentary Pharmacology & Therapeutics. 2013;37:1157.
- AskMayoExpert. Eosinophilic esophagitis (EE). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Eosinophilic esophagitis. American Academy of Asthma, Allergy and Immunology. http://www.aaaai.org/conditions-and-treatments/related-conditions/eosinophilic-esophagitis.aspx. Accessed Jan. 28, 2014.
- Alexander JA (expert opinion). Mayo Clinic, Rochester, Minn. March, 2014.
- Hirano I. Dilation in eosinophilic esophagitis: To do or not to do? Gastrointestinal Endoscopy. 2010;71:713.
- Lucendo AJ, et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: A prospective study on the food cause of the disease. Journal of Allergy and Clinical Immunology. 2013;131:797.
- Katzka DA. The skinny on eosinophilic esophagitis. Gastroenterology. 2013;145:1186.
- Hurrell JM, et al. Prevalence of esophageal eosinophilia varies by climate zone in the United States. American Journal of Gastroenterology. 2012;107:698.
- Dellon ES. Diagnosis and management of eosinophilic esophagitis. Clinical Gastroenterology and Hepatology. 2012;10:1066.
- Safe use of complementary health products and practices. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/safety. Accessed Jan. 2, 2014.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Jan. 2, 2014.
- Fass R. Alternative therapeutic approaches to chronic proton pump inhibitor. Clinical Gastroenterology and Hepatology. 2012;10:338.
- Golden AK. Decision Support System. Mayo Clinic, Rochester, Minn. March 10, 2012.
- U.S. News best hospitals 2013-2014. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings/gastroenterology-and-gi-surgery. Accessed March 9, 2014.