Mayo Clinic is a leader in eosinophilic esophagitis research and actively researches eosinophilic disorders. Mayo researchers have tested the effects of many medications on treatment, including:

  • Steroids
  • Asthma medications
  • Acid-blocking medications

Clinical trials are underway to study long-term management and remission of eosinophilic esophagitis. These include:

  • Diagnosis of PPI-REE
  • Drug treatment using montelukast (Singulair)
  • Oral nitrous oxide levels in patients with eosinophilic esophagitis

Mayo Clinic researchers are also studying the use of a device called the cytosponge as a replacement for endoscopy to monitor ongoing treatment for eosinophilic esophagitis. The cytosponge is a small sponge inside a capsule attached to a string. You swallow the capsule, which dissolves; the doctor then pulls out the sponge, scraping cells off your esophagus. It's quick, inexpensive, minimally invasive and does not require anesthesia.

The Allergic Diseases Research Laboratory at Mayo Clinic in Minnesota investigates the mechanisms of common airway and skin diseases. The lab focuses on and studies types of immune (white blood) cells, especially eosinophils. Laboratories in the areas of clinical immunology and immunotherapeutics, immunology, and gastroenterology and hepatology also are involved in research on eosinophilic disorders.


See a list of publications by Mayo Clinic doctors about eosinophilic esophagitis on PubMed, a service of the National Library of Medicine.

Research profiles

June 19, 2014