Resources Print Mayo Clinic StoreNewsletter: Mayo Clinic Health LetterWebsitesNewsletter: Mayo Clinic Health Letter — Online EditionRequest an Appointment at Mayo Clinic Multimedia Aug. 03, 2016 Share on: FacebookTwitter References Landaw SA, et al. Approach to the adult patient with splenomegaly and other splenic disorders. http://www.uptodate.com/home. Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. http://www.merckmanuals.com/professional/hematology_and_oncology/spleen_disorders/splenomegaly.html. Accessed June 14, 2016. Longo DL, et al. Enlargement of lymph nodes and spleen. In: Harrison’s Principles of Internal Medicine. 19th ed. New York, N.Y.: McGraw-Hill Education; 2015. http://accessmedicine.com. Accessed June 14, 2016. Splenomegaly. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/003276.htm. Accessed June 14, 2016. Recommended adult immunization schedule: United States - 2016. Centers for Disease Control and Prevention. http://www.cdc.gov/vaccines/schedules/hcp/adult.html. Accessed June 14, 2016. Enlarged spleen. The Merck Manuals: Merck Manual Consumer Version. https://www.merckmanuals.com/home/blood-disorders/spleen-disorders/enlarged-spleen. Accessed June 14, 2016. Computed tomography (CT) — Abdomen and pelvis. Radiological Society of North America. http://www.radiologyinfo.org/en/info.cfm?pg=abdominct#preparation. Accessed June 14, 2016. Magnetic resonance imaging (MRI) — Body. Radiological Society of North America. http://www.radiologyinfo.org/en/info.cfm?pg=bodymr#preparation. Accessed June 14, 2016. Bone marrow aspiration and biopsy. Lab Tests Online. https://labtestsonline.org/understanding/analytes/bone-marrow/tab/test/. Accessed June 28, 2016. Mesa RA (expert opinion). Mayo Clinic, Phoenix, Az. June 14, 2016. RelatedSplenectomyNeedle biopsyBone marrow biopsyLiver function testsCT scanX-rayLeukemiaTularemiaEssential thrombocythemiaCastleman diseaseWhipple's diseaseAbdominal painFatigue Enlarged spleen (splenomegaly)OverviewSymptoms & causesDiagnosis & treatmentDiagnosisTreatmentSelf-managementMore aboutIn-DepthMultimediaResources Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Store Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The Mayo Clinic Diet BookMedical News From a Trusted SourceMayo Clinic on Healthy AgingA New Perspective on Alzheimer'sThe Mayo Clinic Diet Online Diagnosis & treatmentRequest an AppointmentDiagnosisTreatment CON-20198836 Patient Care & Health Information Diseases & Conditions Enlarged spleen (splenomegaly)