Many diseases and conditions can cause an enlarged liver, including:
- Hepatitis caused by a virus — including hepatitis A, B and C — or caused by infectious mononucleosis
- Nonalcoholic fatty liver disease
- Alcoholic fatty liver disease
- A disorder that causes abnormal protein to accumulate in your liver (amyloidosis)
- A disorder that causes copper to accumulate in your liver (Wilson's disease)
- A disorder that causes iron to accumulate in your liver (hemachromatosis)
- A disorder that causes fatty substances to accumulate in your liver (Gaucher's disease)
- Fluid-filled pockets in the liver (liver cysts)
- Noncancerous liver tumors, including hemangioma and adenoma
- Obstruction of the gallbladder or bile ducts
- Toxic hepatitis
- Cancer that begins in another part of the body and spreads to the liver
- Liver cancer
Heart and blood vessel problems
April 14, 2012
- Blockage of the veins that drain the liver (Budd-Chiari syndrome)
- Heart failure
- Inflammation of the tissue surrounding the heart (pericarditis)
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- Wolf AD, et al. Hepatomegaly in neonates and children. Pediatrics in Review. 2000;21:303.
- Managing your medications. American Liver Foundation. http://www.liverfoundation.org/mym. Accessed Feb. 8, 2012.
- Seeff LB. Herbal hepatoxicity. Clinics in Liver Disease. 2007;11:577.
- Talwani R, et al. Infectious diseases and the liver. Clinics in Liver Disease. 2011;15:111.
- Liver health and wellness. American Liver Foundation. http://www.liverfoundation.org/abouttheliver/liverhealth. Accessed Feb. 8, 2012.
- Nguyen D, et al. Noninvasive assessment of liver fibrosis. Hepatology. 2011;53:2107.
- Ehman RL (expert opinion). Mayo Clinic, Rochester, Minn. March 1, 2012.