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Factors that increase the risk of endometrial cancer include:
Changes in the balance of female hormones in the body. Your ovaries make two main female hormones — estrogen and progesterone. Fluctuations in the balance of these hormones cause changes in your endometrium.
A disease or condition that increases the amount of estrogen, but not the level of progesterone, in your body can increase your risk of endometrial cancer. Examples include irregular ovulation patterns, such as can occur in women with polycystic ovary syndrome, obesity and diabetes. Taking hormones after menopause that contain estrogen but not progesterone increases the risk of endometrial cancer.
A rare type of ovarian tumor that secretes estrogen also can increase the risk of endometrial cancer.
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