July 31, 2014
Below are current clinical trials.17 studies in Diabetes
(open studies only).
Filter this list of studies by location, status and more.
Increased accumulation of fat into the muscles is associated with what is called insulin-resistant state, which is a pre-diabetic state. The purpose of this research is to find out how fat circulating in the blood following fat consumption is taken up by the muscles in healthy people as well as people that are insulin-resistant. The investigators are specifically interested in how a hormone called insulin is involved in this process. Findings from this research will contribute to our understanding of why insulin-resistant people have increased accumulation of fat in their muscles, and ultimately help to design appropriate interventions to prevent type 2 Diabetes.
The purpose of this study is to evaluate the effects of improving glycemic control, and/or reducing glycemic variability on gastric emptying, intestinal barrier function, autonomic nerve functions, and epigenetic changes in subjects with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) who are switched to intensive insulin therapy as part of clinical practice.
The purpose of this study is to test the hypothesis that patients with T2DM will have greater deterioration in BMSi and in cortical porosity over 3 yrs as compared to sex- and age-matched non-diabetic controls; and identify the circulating hormonal (e.g., estradiol [E2], testosterone [T]) and biochemical (e.g., bone turnover markers, AGEs) determinants of changes in these key parameters of bone quality, and evaluate the possible relationship between existing diabetic complications and skeletal deterioration over time in the T2DM patients.
The purpose of this study is to evaluate glucose variability in patients with type 1 diabetes (T1D) and insulin antibodies, to evaluate the clinical significance of insulin antibodies, and to establish an in vitro assay that would detect antibodies to insulin and insulin analogs.
Hypothesis: Increased contact with the diabetes care team throughout pregnancy will lead to improved glucose control during pregnancy.
The purpose of this study is to estimate the risk of diabetes related complications after total pancreatectomy. We will contact long term survivors after total pancreatectomy to obtain data regarding diabetes related end organ complications.
Adults who gain most of their excess weight in abdominal area or have Type 2 (adult onset) Diabetes typically do not process sugar (glucose) normally in their muscle in response to insulin, especially compared to lean adults or those who have gained most of their excess body fat in their hip and thigh areas. We know that some of this is due to differences in how fat cells release fat molecules into the bloodstream, which in turn affects muscle metabolism. We don’t know whether fat molecules in the bloodstream are handled differently by those with abdominal fat gain, type 2 diabetes or hip and thigh fat gain compared with lean adults. By measuring how muscle handles fat molecules in the bloodstream and how that relates to the ability of insulin to help the muscle use glucose, we will help understand the interaction between fat cells and muscle as it relates to diabetes-related diseases.
- Papadakis MA, ed., et al. Current Medical Diagnosis & Treatment 2014. 53rd ed. New York, N.Y.: The McGraw-Hill Companies; 2014. http://accessmedicine.mhmedical.com/book.aspx?bookId=330. Accessed April 27, 2014.
- Standards of medical care in diabetes — 2014. Diabetes Care. 2014;37:s14.
- Diabetes mellitus (DM). The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/diabetes_mellitus_and_disorders_of_carbohydrate_metabolism/diabetes_mellitus_dm.html. Accessed April 29, 2014.
- Atkinson MA, et al. Type 1 diabetes. The Lancet. 2014;383:69.
- What is gestational diabetes? American Diabetes Association. http://www.diabetes.org/diabetes-basics/gestational/what-is-gestational-diabetes.html. Accessed May 9, 2014.
- Gardner DG, et al. Greenspan's Basic & Clinical Endocrinology. 9th ed. New York, N.Y.: The McGraw-Hill Companies; 2011. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=13. Accessed April 27, 2014.
- Diabetes & pregnancy. Centers for Disease Control and Prevention. http://www.cdc.gov/Features/DiabetesPregnancy/. Accessed May 9, 2014.
- Gestational diabetes mellitus. Washington, D.C.: American Congress of Obstetricians and Gynecologists. http://www.guideline.gov/content.aspx?id=47014. Accessed May 9, 2014.
- Levitsky LL, et al. Special situations in children and adolescents with type 1 diabetes mellitus. http://www.uptodate.com/home. Accessed April 27, 2014.
- Peyser T, et al. The artificial pancreas: Current status and future prospects in the management of diabetes. Annals of the New York Academy of Sciences. 2014;1311:102.
- Bergenstal RM, et al. Threshold-based insulin-pump interruption for reduction of hypoglycemia. New England Journal of Medicine. 2013;369:224.
- Hyperglycemia (High blood glucose). American Diabetes Association. http://www.diabetes.org/living-with-diabetes/treatment-and-care/blood-glucose-control/hyperglycemia.html. Accessed April 29, 2014.
- DKA (ketoacidosis) & ketones. American Diabetes Association. http://www.diabetes.org/living-with-diabetes/complications/ketoacidosis-dka.html. Accessed April 29, 2014.
- Natural medicines in the clinical management of diabetes. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed May 10, 2014.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. Accessed May 6, 2014.
- Diabetes and metabolism — The how of clinical studies. Discovery's Edge: Mayo Clinic's Online Research Magazine. http://www.mayo.edu/research/discoverys-edge/diabetes-metabolism-how-clinical-studies. Accessed May 10, 2014.