Antidepressants can cause unpleasant side effects. Symptoms such as nervousness, headache and upset stomach are common initially. For many people, these improve within a few weeks of starting an antidepressant. In some cases, however, antidepressants cause side effects that don't go away.
Talk to your doctor or mental health provider about any side effects you're having. Rarely, antidepressants can cause serious side effects that need to be treated right away.
If side effects seem intolerable, you may be tempted to stop taking an antidepressant or to reduce your dose on your own. Don't do it. Your symptoms may return, and stopping your antidepressant suddenly may cause withdrawal-like symptoms.
Click on the links at left to see coping strategies for the most common antidepressant side effects.
Nausea typically begins within a week of starting an antidepressant. It may go away after a few weeks when your body adjusts to the medication.
- Take your antidepressant with food, unless otherwise directed.
- Eat smaller, more frequent meals.
- Suck on sugarless hard candy.
- Drink plenty of fluids, such as cool water or ginger ale that's lost its carbonation.
- Try an antacid or bismuth subsalicylate (Pepto-Bismol, others).
- Talk to your doctor about a dosage change or a slow-release form of the medication.
Increased appetite, weight gain
You may gain weight because of fluid retention or lack of physical activity, or because you have a better appetite when your depression symptoms ease up. Some antidepressants are more likely to cause weight gain than others. Examples of antidepressants that may be less likely to cause weight gain include:
- Bupropion (Wellbutrin)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Sertraline (Zoloft)
- Venlafaxine (Effexor XR)
- Cut back on sweets and sugary drinks.
- Select lower calorie nutritious foods, such as vegetables and fruits, and avoid saturated and trans fats.
- Eat smaller, more frequent meals and eat more slowly.
- Keep a food diary — tracking what you eat can help you manage your weight.
- Seek advice from a registered dietitian.
- Get regular physical activity or exercise most days of the week.
- Talk to your doctor about switching medications, but get the pros and cons.
Sexual side effects
Most antidepressants cause sexual side effects that can last throughout treatment. They can include decreased sex drive and difficulty reaching orgasm. Some antidepressants may cause trouble getting or keeping an erection (erectile dysfunction). Selective serotonin reuptake inhibitors (SSRIs) are more likely to cause sexual side effects than other antidepressants are.
- Consider a medication that requires only a once-a-day dose, and schedule sexual activity before taking that dose.
- Talk to your doctor about adding or switching to an antidepressant that may counteract these effects, such as bupropion (Wellbutrin).
- Talk to your doctor about a "drug holiday" — stopping medication for a day or so each week to temporarily ease symptoms.
- If you are a man, a medication such as sildenafil (Viagra), vardenafil (Levitra, Staxyn) or tadalafil (Cialis) may temporarily ease sexual side effects. In women, estrogen cream is sometimes used.
- Talk to your partner about your sexual side effects and how they change your needs. Adjusting your sexual routine may be helpful. For example, you may need a longer period of foreplay before having sexual intercourse.
Fatigue and drowsiness are common, especially during early weeks of treatment with an antidepressant.
- Take a brief nap during the day.
- Get some physical activity, such as walking.
- Avoid driving or operating dangerous machinery until the fatigue passes.
- Take your antidepressant one to two hours before bedtime.
- Talk to your doctor to see if adjusting your dose will help.
You may experience insomnia because some antidepressants give you an energy boost. While that may sound appealing, it can also make it difficult to get to sleep or stay asleep — and you may be tired during the day.
- Take your antidepressant in the morning.
- Avoid caffeinated food and drinks, particularly late in the day.
- Get regular physical activity or exercise — but complete it several hours before bedtime so it doesn't interfere with your sleep.
- Talk to your doctor about taking a sedating medication at bedtime.
- If insomnia is an ongoing problem, ask your doctor whether taking a low dose of a sedating antidepressant such as trazodone or mirtazapine (Remeron) before bed might help.
Dry mouth is a common side effect of many antidepressants.
- Sip water regularly or suck on ice chips.
- Chew sugarless gum or suck on sugarless hard candy.
- Avoid caffeine because it can make your mouth drier.
- Breathe through your nose, not your mouth.
- Brush your teeth twice a day, floss daily and see your dentist regularly. Having a dry mouth can increase your risk of getting cavities.
- Talk to your doctor about using a moisturizing mouth spray or another product that might stimulate saliva production.
Blurred vision is a common side effect, but it usually goes away on its own within a couple of weeks of starting an antidepressant. With certain antidepressants, such as tricyclic antidepressants, it may be an ongoing issue.
- Talk to your doctor about using special eyedrops to relieve dryness.
- Talk to your doctor about changing your antidepressant or lowering your dose.
- Get an eye exam to see whether blurred vision caused by an antidepressant may be worsened by an underlying eye problem.
Constipation is often associated with tricyclic antidepressants because they disrupt normal functioning of the digestive tract and other organ systems. Other antidepressants sometimes cause constipation as well.
- Drink plenty of water.
- Eat high-fiber foods, such as fresh fruits and vegetables, brans, and whole grains.
- Get regular exercise.
- Take a fiber supplement (Citrucel, Konsyl, Metamucil, others).
- Consider taking stool softeners if other measures don't work.
Dizziness is more common with tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) than with other antidepressants. These medications can cause low blood pressure, resulting in dizziness.
- Rise slowly from sitting or standing positions.
- Use handrails, canes or other sturdy items for support.
- Avoid driving or operating machinery.
- Avoid caffeine, tobacco and alcohol.
- Drink plenty of fluids.
- Take your antidepressant at bedtime.
Agitation, restlessness, anxiety
Agitation, restlessness or anxiety can result from the stimulating effect of certain antidepressants. Although having more energy can be a good thing, it may mean you can't relax or sit still even if you want to. Be alert for racing or impulsive thoughts along with high energy. If these develop, talk to your doctor right away because they may be signs of bipolar disorder or another serious disorder.
- Get regular exercise, such as jogging, biking or aerobics, or some type of physical activity, such as walking. Talk to your doctor first about what would be a good type of exercise or physical activity for you.
- Practice deep-breathing exercises, muscle relaxation or yoga.
- Consult your doctor about temporarily taking a relaxing or sedating medication or switching to an antidepressant that isn't as stimulating.
Jul. 09, 2013
- Katon W, et al. Initial treatment of depression in adults. http://www.uptodate.com/home. Accessed May 30, 2013.
- Bostwick JM. A generalist's guide to treating patients with depression with an emphasis on using side effects to tailor antidepressant therapy. Mayo Clinic Proceedings. 2010;85:538.
- Mental health medications. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/mental-health-medications/index.shtml. Accessed May 30, 2013.
- Anderson HD, et al. Rates of 5 common antidepressant side effects among adult and adolescent cases of depression: A retrospective US claims study. Clinical Therapeutics. 2012;34:113.
- Kung S (expert opinion). Mayo Clinic, Rochester, Minn. June 17, 2013.
- Hall-Flavin DK (expert opinion). Mayo Clinic, Rochester, Minn. June 19, 2013.