Quality CareFind out why Mayo Clinic is the right place for your health care. Make an appointment.
Meet the StaffFind a directory of doctors and departments at all Mayo Clinic campuses. Visit now.
Research and Clinical TrialsSee how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care. Explore now.
Visit Our SchoolsEducators at Mayo Clinic train tomorrow’s leaders to deliver compassionate, high-value, safe patient care. Choose a degree.
Professional ServicesExplore Mayo Clinic’s many resources and see jobs available for medical professionals. Get updates.
Give to Mayo ClinicHelp set a new world standard in care for people everywhere. Give now.
Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.
Subscribe to Housecall
Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
Fish oil supplements may help ease symptoms of depression in some people. Some studies in adults suggest that omega-3 fatty acids may be beneficial in the treatment of mild to moderate depression, but more research is needed.
Fish oil is a good source of omega-3 fatty acids, which play an important role in brain function. People with depression may have low blood levels of brain chemicals called eicosapentaenoic (i-koe-suh-pen-tuh-e-NO-ik) acid (EPA) and docosahexaenoic (doe-koe-suh-hek-suh-e-NO-ik) acid (DHA). EPA and DHA can be found in fish oil.
Eating fish a few times a week may provide your body with these healthy oils. Examples of fish high in omega-3s include sardines, salmon, herring, trout and canned white (albacore) tuna.
If you're pregnant or nursing, due to mercury levels, limit your weekly fish intake to 12 ounces (340 grams) of a variety of fish and make wise choices. For example, salmon is typically low in mercury. But eat no more than 6 ounces (170 grams) of canned white tuna a week because it's higher in mercury than light canned tuna.
However, while it's generally true that the best way to get nutrients is through healthy foods, this is one example where a supplement may help. Some studies have shown that contaminants like mercury do not appear to accumulate in fish oil, but remain primarily in the meat of the fish. So if you're concerned about mercury, a high-quality fish oil supplement may help with depression, but ask your doctor for advice.
Fish oil isn't considered a replacement for treatment of depression, but it may be helpful as an addition to prescribed medications or other treatment. Although more studies are needed to determine exactly what role omega-3s play in depression, it's possible that fish oil supplements high in omega-3s may help lower the risk of depression — and omega-3 fatty acids help protect heart health.
Daniel K. Hall-Flavin, M.D.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not for profit mission.
Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.
We comply with the HONcode standard for trustworthy health information: verify here.