Treatments and drugs

By Mayo Clinic Staff

Treatment of depersonalization-derealization disorder is primarily psychological counseling, also called talk therapy. However, sometimes medications may be added to your treatment plan.

  • Psychological counseling. This helps you understand why depersonalization and derealization occur, and helps you gain control over the symptoms so that they go away. Two such techniques include cognitive behavioral therapy and psychodynamic therapy. Depersonalization-derealization disorder may also improve when counseling helps with other mental health conditions, such as depression.
  • Medications. While there are no medications specifically approved to treat depersonalization-derealization disorder, certain medications that are used to treat depression and anxiety may help. Examples that have been shown to relieve symptoms include fluoxetine (Prozac), clomipramine (Anafranil) and clonazepam (Klonopin).
May. 24, 2014

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