Cyclic vomiting syndrome is characterized by episodes of severe vomiting that have no apparent cause. Episodes can last for hours or days and alternate with relatively symptom-free periods of time. Each episode is similar to previous ones, meaning that episodes tend to start at the same time of day, last the same length of time and occur with the same symptoms and level of intensity.
Once thought to affect only children, cyclic vomiting syndrome occurs in all age groups. Research suggests that cyclic vomiting syndrome may affect almost 2 percent of school-age children and that the number of cases diagnosed in adults is increasing.
Cyclic vomiting syndrome may be related to migraines. Episodes can be so severe that the person has to stay in bed for days.
The syndrome is difficult to diagnose because vomiting is a symptom of many disorders. Treatment generally involves managing symptoms and lifestyle changes to help prevent the events that can trigger vomiting episodes. Medications, including anti-nausea and migraine therapies, may help lessen symptoms.
April 19, 2013
Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed Feb. 15, 2013.
- Choung RS, et al. Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males. Neurogastroenterology & Motility. 2012;24:20.
- Cyclic vomiting syndrome. National Digestive Diseases Information Clearinghouse. http://digestive.niddk.nih.gov/ddiseases/pubs/cvs/index.aspx. Accessed Feb. 18, 2013.
- Kumar N, et al. Cyclic vomiting syndrome (CVS): Is there a difference based on onset of symptoms — pediatric versus adult? BMC Gastroenterology. 2012;12:52.
- Drumm BR, et al. Cyclical vomiting syndrome in children: A prospective study. Neurogastroenterology & Motility. 2012;24:922.
- Kliegman RM, et al. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/das/book/body/208746819-6/0/1608/0.html. Accessed Feb. 18, 2013.
- Hejazi RA, et al. Review article: Cyclic vomiting syndrome in adults - rediscovering and redefining an old entity. Alimentary Pharmacology & Therapeutics. 2011;34:263.
- AskMayoExpert. When should patients with nausea and vomiting be referred for subspecialty evaluation? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
- Longo DL, et al. Harrison's Principles of Internal Medicine. 18th ed. New York, N.Y.: McGraw-Hill; 2012. http://www.accessmedicine.com/content.aspx?aID=9112783. Accessed Feb. 15, 2013.
- Slutsker B, et al. Breaking the cycle: Cognitive behavioral therapy and biofeedback training in a case of cyclic vomiting syndrome. Psychology, Health & Medicine. 2010;15:625.
- Boles RG. High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series. BMC Neurology. 2011;11:102.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.mdconsult.com/das/book/body/208746819-2/0/1494/0.html. Accessed March 3, 2013.
- Hoecker JL (expert opinion). Mayo Clinic, Rochester, Minn. March 4, 2013.