Diagnosis By Mayo Clinic Staff Print You may undergo the following tests to diagnose cryptosporidium infection: Acid-staining test. The simplest way to diagnose cryptosporidium infection is a method called an acid-staining test, which identifies cryptosporidium under a microscope. To obtain cells for the analysis, your doctor might ask for a stool sample, or in more extreme cases, take a tissue sample (biopsy) from your intestine for the test. Stool culture. Your doctor might also order a standard stool culture. Although this test cannot detect the presence of cryptosporidium, it may help rule out other bacterial pathogens. Other tests. Once it's clear that your infection is caused by cryptosporidium parasites, you may need further testing to check for development of serious complications. For example, checking liver and gallbladder function may determine whether the infection has spread. If you have both AIDS and cryptosporidiosis, a T-cell count — which measures the level of a certain white blood cell that's part of your immune system — can help predict the duration of the cryptosporidiosis. A T-cell count under 100 cells per microliter means you're more likely to have complications. Request an Appointment at Mayo Clinic Symptoms & causesTreatment Nov. 30, 2016 Print Share on: FacebookTwitter References Ray CG, et al. Apicomplexa and microsporidia. In: Sherris Medical Microbiology. 6th ed. New York, N.Y.: The McGraw-Hill Companies; 2014. http://www.accessmedicine.com. Accessed Sept. 19, 2016. Longo DL, et al., eds. Protozoal intestinal infections and trichomoniasis. In: Harrison's Principles of Internal Medicine. 19th ed. New York, N.Y.: McGraw-Hill Education; 2015. http://accessmedicine.com. Accessed Sept. 19, 2016. Leder K, et al. Epidemiology, clinical manifestations, and diagnosis of cryptosporidiosis. http://www.uptodate.com/home. Accessed Sept. 19, 2016. Parasites — Cryptosporidium: Prevention & control. Centers for Disease Control and Prevention. http://www.cdc.gov/parasites/crypto/prevention-control.html. Accessed Sept. 19, 2016. Levinson W. Intestinal and urogenital — protozoa. In: Review of Medical Microbiology and Immunology. 14th ed. New York, N.Y.: McGraw-Hill Education; 2016. http://www.accessmedicine.com. Accessed Sept. 19, 2016. Leder K, et al. Treatment and prevention of cryptosporidiosis. http://www.uptodate.com/home. Accessed Sept. 19, 2016. RelatedChildren's swimmingLiver function testsNausea and vomitingUnexplained weight lossDiarrhea Cryptosporidium infectionOverviewSymptoms & causesDiagnosis & treatmentDiagnosisTreatmentPreparing for your appointmentSelf-managementMore aboutIn-DepthResourcesNews from Mayo Clinic Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Store Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The Mayo Clinic Diet BookMedical News From a Trusted SourceMayo Clinic on Healthy AgingA New Perspective on Alzheimer'sThe Mayo Clinic Diet Online Diagnosis & treatmentRequest an AppointmentDiagnosisTreatmentPreparing for your appointment CON-20164036 Patient Care & Health Information Diseases & Conditions Cryptosporidium infection