• Sex. Women are far more likely to develop limited scleroderma than men are.
  • Race. In the United States, limited scleroderma affects women of African descent more often than women of European descent. Choctaw Native Americans also have higher rates of limited scleroderma than other races.
  • Genetic factors. If someone in your family has an autoimmune disease — such as lupus, rheumatoid arthritis or Hashimoto's disease — you have an increased risk of developing limited scleroderma.
  • Exposure to toxins. Toxic substances, such as polyvinyl chloride, benzene, silica and trichloroethylene, may trigger scleroderma in people with a genetic predisposition to the disease.
Jun. 02, 2011