Coronary artery disease is thought to begin with damage or injury to the inner layer of a coronary artery, sometimes as early as childhood. The damage may be caused by various factors, including:
- High blood pressure
- High cholesterol
- Diabetes or insulin resistance
- Radiation therapy to the chest, as used for certain types of cancer
- Sedentary lifestyle
Once the inner wall of an artery is damaged, fatty deposits (plaques) made of cholesterol and other cellular waste products tend to accumulate at the site of injury in a process called atherosclerosis. If the surface of these plaques breaks or ruptures, blood cells called platelets will clump at the site to try to repair the artery. This clump can block the artery, leading to a heart attack.
Apr. 12, 2014
- Coronary heart disease. National Lung, Heart, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/Cad/CAD_WhatIs.html. Accessed October 6, 2013.
- Smith SC, et al. American Heart Association/American College of Cardiology Foundation Secondary prevention and risk reduction therapy for patients with coronary and other Atherosclerotic Vascular Disease: 2011 update. Circulation. 2011;124:2458.
- The seventh report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Bethesda, Md.: National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/guidelines/hypertension/jnc7full.htm. Accessed Oct. 3, 2013.
- Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/guidelines/cholesterol/index.htm. Accessed Oct. 6, 2013.
- Natural product effectiveness checker: High cholesterol. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Oct. 3, 2013.
- Natural product effectiveness checker: Hypertension. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Oct. 3, 2013.
- Omega-3 supplements: An introduction. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/omega3/introduction.htm. Accessed Oct. 6, 2013.
- Wilson PWF. Overview of possible risk factors for cardiovascular disease. http://www.uptodate.com/home. Accessed Oct. 6, 2013.
- Hanson MA, et al. Coronary Artery Disease. Primary Care: Clinics in Office Practice. 2013;40:1.
- Wilson PWF. Overview of the risk equivalents and established risk factors for cardiovascular disease. http://www.uptodate.com/home. Accessed Oct. 6, 2013.
- Weintraub H. Update on marine omega-3 fatty acids: Management of dyslipidemia and current omega-3 treatment options. Atherosclerosis. 2013;230:381.
- Grogan M (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 16, 2013.
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