Below are current clinical trials.6 studies in COPD
(open studies only).
Filter this list of studies by location, status and more.
The purpose of this study is to assess the effect of metoprolol for patients who have moderate to severe COPD, measuring the time to first acute exacerbation (episode of worsening), the rates and severity of exacerbations, any cardiovascular events, all-causes of death, lung function, difficulty breathing, quality of life and any metoprolol-related side effects.
As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.
The primary objective of this proposal is to develop a Thoracic Specimen Registry at Mayo Clinic. The purpose of the registry will be to support ongoing research in the etiology, early diagnosis, clinical management, and prognosis of lung cancer and other cancers and diseases of the thorax by developing a complete repository of specimens from patients with thoracic disease including but not limited to suspected lung cancer, mediastinal and pleural tumors and from patients at a very high risk of developing other thoracic cancers or other thoracic diseases.
The purpose of this study is to assess the safety and effectiveness of PT009 compared with PT005 for the prevention of moderate to very severe episodes of worsening COPD and lung function.
Regular physical activity has been found to be important in maintaining health and well-being in people with COPD. The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more physically active in their daily lives.
This is a multicenter, prospective, randomized, controlled study designed to evaluate improvement of lung function after treatment with the Spiration Valve System as compared to medical management in the control group. The control group will be evaluated in the same manner as the treatment group.
The Spiration Valve is a small, umbrella-shaped, one-way valve that is placed inside the airways of one lung. It is used to redirect air from the less healthy to the more healthy parts of the lung. This helps to reduce over-inflation and may improve overall lung function and quality of life for people living with emphysema.
July 12, 2016
- What is COPD? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/copd. Accessed Feb. 11, 2016.
- Ferri FF. Chronic obstructive pulmonary disease. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Feb. 11, 2016.
- Han MK, et al. Chronic obstructive pulmonary disease: Definition, clinical manifestations, diagnosis, and staging. http://www.uptodate.com/home. Accessed Feb. 15, 2016.
- Balkissoon R, et al. Chronic obstructive pulmonary disease: A concise review. Medical Clinics of North America. 2011;95:1125.
- Foreman M, et al. Genes and COPD. Medical Clinics of North America. 2012;96:699.
- Longo DL, et al., eds. Chronic obstructive pulmonary disease. In: Harrison's Principles of Internal Medicine. 19th ed. New York, N.Y.: McGraw-Hill Education; 2015. http://www.accessmedicine.com. Accessed Feb. 15, 2016.
- Pagon RA, et al., eds. Alpha-1 antitrypsin deficiency. In: GeneReviews. Seattle, Wash.: University of Seattle, Washington; 1993-2016. http://www.ncbi.nlm.nih.gov/books/NBK1116. Accessed March 23, 2016.
- Hillas G, et al. Managing comorbidities in COPD. International Journal of Chronic Obstructive Pulmonary Disease. 2015;10:95.
- Standards for the diagnosis and management of patients with COPD. American Thoracic Society. http://www.thoracic.org/copd-guidelines/index.php. Accessed March 23, 2016.
- Ferguson GT, et al. Management of stable chronic obstructive pulmonary disease. http://www.uptodate.com/home. Accessed Feb. 15, 2016.
- Barbara Woodward Lips Patient Education Center. Chronic obstructive pulmonary disease (COPD). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
- Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. March 22, 2016.
- Stoller JK. Management of exacerbations of chronic obstructive pulmonary disease. http://www.uptodate.com/home. Accessed March 23, 2016.
- Mallea JM (expert opinion). Mayo Clinic, Jacksonville, Fla. April 26, 2016.
- What are the benefits of quitting smoking? National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/health-topics/topics/smo/benefits. Accessed April 27, 2016.
- Jha P, et al. 21st-century hazards of smoking and benefits of cessation in the United States. The New England Journal of Medicine. 2013;368:341.