Below are current clinical trials.4 studies in Constipation
(open studies only).
Filter this list of studies by location, status and more.
Constipation is a very common problem. Western style toilets that are nearly universal in the United States require the person to sit on the toilet. However, results from uncontrolled studies suggests that a squatting posture (as prevalent in many foreign countries) may be better at facilitating evacuation compared to a Western style commode. One uncontrolled, unpublished study suggests that a footstool improved bowel symptoms in nearly 98% of 153 constipated participants. The purpose of this study is to evaluate the benefits of a footstool on symptoms and anorectal function in constipated patients.
The purpose of this study is to develop a resource (bank) of biospecimens and data collected from individuals with functional gastrointestinal disorders (FGID) to facilitate discovery and development of novel microbial biomarkers of disease and response to treatment, and novel targeted therapeutic strategies for FGID.
The purpose of this study is to better understand the mechanisms by which people retain control of their bowel contents and evacuate stool (defecation) and why people have constipation or fecal incontinence (involuntary stool leakage). Pressure measurements (by manometry) and magnetic resonance imaging (MRI) are widely used for diagnosis in patients with constipation or fecal incontinence. This study is trying to improve the utility of these tests for diagnosing these problems and to understand if pressure measurements (by manometry) can be related to strength of the anal sphincter measured by MRI. To do this, we will study the effects of alfuzosin on these muscles.
Many people have constipation because they cannot defecate. However, we do not fully understand the mechanisms of normal defecation or constipation. We are trying to better understand why constipation occurs and improve the tests for diagnosing these conditions.
Oct. 19, 2016
- Constipation. National Digestive Diseases Information Clearinghouse. http://digestive.niddk.nih.gov/ddiseases/pubs/constipation/index.aspx. Accessed July 17, 2016.
- U.S. News best hospitals 2015-2016. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings/gastroenterology-and-gi-surgery. Accessed April 6, 2016.
- Bharucha AE, et al. American Gastroenterological Association Medical Position Statement on Constipation. Gastroenterology. 2013;144:211.
- Rakel D. Constipation. In: Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed July 17, 2016.
- Feldman M, et al. Constipation. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed July 17, 2016.
- 2015-2020 Dietary Guidelines for Americans. U.S. Department of Health and Human Services and U.S. Department of Agriculture. http://health.gov/dietaryguidelines/2015/guidelines. Accessed July 17, 2016.
- Wald A. Etiology and evaluation of chronic constipation in adults. http://www.uptodate.com/home. Accessed July 17, 2016.
- Wald A. Management of chronic constipation in adults. http://www.uptodate.com/home. Accessed July 17, 2016.
- Brown AY. Allscripts EPSi. Mayo Clinic, Rochester, Minn. May 4, 2016.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. August 7, 2016.