Common variable immunodeficiency (CVID) is an immune system disorder in which you have low levels of several of the proteins (antibodies) that help you fight infections. CVID leaves you open to recurrent infections in your ears, sinuses and respiratory system, and increases your risk of digestive disorders, blood disorders and cancer.

Signs and symptoms of common variable immunodeficiency may appear during childhood or adolescence, though most people don't experience them until adulthood. The condition can be inherited, or it can be acquired during your lifetime.

  • Expertise. Mayo Clinic doctors trained in immune system disorders have expertise in caring for people with CVID and other primary immunodeficiency conditions. The Primary Immunodeficiency Center at Mayo Clinic in Rochester, Minnesota, is a designated referral center for the Jeffrey Modell Foundation — a nonprofit organization that promotes and conducts research for primary immunodeficiency disorders. In addition, the Department of Medical Genetics includes clinical geneticists who are physicians certified in primary immunodeficiency conditions.
  • Diagnosis and treatment experience. Mayo Clinic doctors provide timely diagnosis and treatment of CVID and work closely with you to provide the most appropriate care for your needs or your child's. Treatments for CVID focus on decreasing the frequency and the severity of your infections and may include immunoglobulin and antibiotic therapies. Doctors trained in pediatric immunodeficiency disorders care for children with CVID and other immune system disorders.
  • Genetic counseling. Analysis of your DNA can reveal whether you have inherited the gene that causes CVID. Mayo Clinic's Department of Medical Genetics can help you understand how a genetically based disorder, such as common variable immunodeficiency, affects you or your child and your family.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Doctors trained in allergy, asthma and clinical immunology care for adults with common variable immunodeficiency at Mayo Clinic in Phoenix/Scottsdale, Arizona.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases care for adults and sometimes children with common variable immunodeficiency at Mayo Clinic in Jacksonville, Florida.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases in the Primary Immunodeficiency Center and other areas care for people with common variable immunodeficiency at Mayo Clinic in Rochester, Minnesota.

For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.

See information on patient services at the three Mayo Clinic locations, including transportation options and lodging.

Doctors trained in immune system disorders and other areas conduct basic and clinical research in potential diagnostic tests and treatments for common variable immunodeficiency. Staff in the Primary Immunodeficiency Center at Mayo Clinic in Minnesota conduct research in CVID and other primary immunodeficiency conditions.

Publications

See a list of publications by Mayo authors on PubMed, a service of the National Library of Medicine.

Jan. 10, 2015