Factors that may contribute to the formation of colon polyps or cancer include:
- Age. Most people with colon polyps are 50 or older.
- Inflammatory intestinal conditions, such as ulcerative colitis and Crohn's disease.
- Family history. You're more likely to develop colon polyps or cancer if you have a parent, sibling or child with them. If many family members have them, your risk is even greater. In some people, this connection isn't hereditary.
- Tobacco and alcohol use.
- Obesity and lack of exercise.
- Race. African-Americans are at higher risk of developing colon cancer.
- Type 2 diabetes that isn't well-controlled.
Hereditary polyp disorders
Rarely, people inherit genetic mutations that cause colon polyps to form. If you have one of these genetic mutations, you are at much higher risk of developing colorectal cancer. Screening and early detection can help prevent the development or spread of these cancers.
Hereditary disorders that cause colon polyps include:
Aug. 12, 2014
- Lynch syndrome, also called hereditary nonpolyposis colorectal cancer. People with Lynch syndrome tend to develop relatively few colon polyps, but those polyps can quickly become malignant. Lynch syndrome is the most common form of inherited colon cancer and is also associated with tumors in the breast, stomach, small intestine, urinary tract and ovary.
- Familial adenomatous polyposis (FAP), a rare disorder that causes hundreds or even thousands of polyps to develop in the lining of your colon beginning during your teenage years. If the polyps aren't treated, your risk of developing colon cancer is nearly 100 percent, usually before age 40. Genetic testing can help determine your risk of FAP.
- Gardner's syndrome, a variant of FAP that causes polyps to develop throughout your colon and small intestine. You may also develop noncancerous tumors in other parts of your body, including your skin, bones and abdomen.
- MYH-associated polyposis (MAP), a condition similar to FAP that is caused by mutations in the MYH gene. People with MAP often develop multiple adenomatous polyps and colon cancer at a young age. Genetic testing can help determine your risk of MAP.
- Peutz-Jeghers syndrome, a condition that usually begins with freckles developing all over the body, including the lips, gums and feet. Then noncancerous polyps develop throughout the intestines. These polyps may become malignant, so people with this condition have an increased risk of colon cancer.
- Serrated polyposis syndrome, a condition that leads to multiple serrated adenomatous polyps in the upper part of the colon. These polyps may become malignant.
- Ahnen DJ, et al. The approach to the patient with colonic polyps. http://www.uptodate.com/home. Accessed March 25, 2014.
- Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.clinicalkey.com. Accessed March 28, 2014.
- Goldman L, et al. Goldman's Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed March 27, 2014.
- AskMayoExpert. Why is surveillance of colorectal polyps important? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
- Elmunzer BJ. Endoscopic resection of sessile colon polyps. Gastroenterology. 2013;144:30.
- Baron TH, et al. Recommended intervals between screening and surveillance colonoscopies. Mayo Clinic Proceedings. 2013;88:854.
- Kennedy RD, et al. The natural history of familial adenomatous polyposis syndrome: A 24 year review of a single center experience in screening, diagnosis, and outcomes. Journal of Pediatric Surgery. 2014;49:82.
- Sharma P, et al. Advanced imaging in colonoscopy and its impact on quality. Gastrointestinal Endoscopy. 2014;79:28.
- Hegde M, et al. ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). Genetics in Medicine. 2014;16:101.
- What I need to know about colon polyps. National Digestive Diseases Information Clearinghouse. http://digestive.niddk.nih.gov/ddiseases/pubs/colonpolyps_ez/#what. Accessed March 29, 2014.
- Ahnen DJ, et al. Colorectal cancer: Epidemiology, risk factors, and protective factors. http://www.uptodate.com/home. Accessed April 4, 2014.
- Golden AK. Decision Support System. Mayo Clinic, Rochester, Minn. March 10, 2014.
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