Risk factorsBy Mayo Clinic Staff
Several factors may increase the likelihood of a baby developing a cleft lip and cleft palate, including:
June 17, 2015
- Family history. Parents with a family history of cleft lip or cleft palate face a higher risk of having a baby with a cleft.
- Race. In the United States, cleft lip and palate are reportedly most common in Native Americans and least common in African-Americans.
- Sex. Males are twice as likely to have a cleft lip with or without cleft palate. Cleft palate without cleft lip is more common in females.
- Exposure to certain substances during pregnancy. Cleft lip and cleft palate may be more likely to occur in pregnant women who smoke cigarettes, drink alcohol or take certain medications.
- Having diabetes. There is some evidence that women diagnosed with diabetes before pregnancy may have an increased risk of having a baby with a cleft lip with or without a cleft palate.
- Being obese during pregnancy. There is some evidence that babies born to obese women may have increased risk of cleft lip and palate.
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- Cleft lip and cleft palate. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/birthdefects/cleftlip.html. Accessed May 12, 2015.
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