CausesBy Mayo Clinic Staff
Cleft lip and cleft palate occur when tissues in the baby's face and mouth don't fuse properly. Normally, the tissues that make up the lip and palate fuse together in the second and third months of pregnancy. But in babies with cleft lip and cleft palate, the fusion never takes place or occurs only part way, leaving an opening (cleft).
Researchers believe that most cases of cleft lip and cleft palate are caused by an interaction of genetic and environmental factors. In many babies, a definite cause isn't discovered.
The mother or the father can pass on genes that cause clefting, either alone or as part of a genetic syndrome that includes a cleft lip or cleft palate as one of its signs. In some cases, babies inherit a gene that makes them more likely to develop a cleft, and then an environmental trigger actually causes the cleft to occur.
June 17, 2015
- Wilkins-Haug L. Etiology, prenatal diagnosis, obstetrical management and recurrence of orofacial clefts. http://www.uptodate.com/home. Accessed May 12, 2015.
- Crockett DJ, et al. Cleft lip and palate. Facial Plastic Surgery Clinics of North America. 2014;22:573.
- Cleft lip and cleft palate surgery. American Society of Plastic Surgeons. http://www.plasticsurgery.org/reconstructive-procedures/cleft-lip-and-palate.html#content. Accessed May 12, 2015.
- Campbell A, et al. Cleft lip and palate surgery: An update of clinical outcomes for primary repair. Oral and Maxillofacial Surgery Clinics of North America. 2010;22:43.
- Cleft lip and cleft palate. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/birthdefects/cleftlip.html. Accessed May 12, 2015.
- Cleft lip and cleft palate. American Speech-Language-Hearing Association. http://www.asha.org/public/speech/disorders/cleftlip/. Accessed May 12, 2015.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. Jan. 23, 2015.
- Your baby's first year. Cleft Palate Foundation. http://www.cleftline.org/parents-individuals/publications/booklets/. Accessed May 13, 2015.
- Parameters for evaluation and treatment of patients with cleft lip/palate or other craniofacial anomalies. American Cleft Palate-Craniofacial Association. http://www.acpa-cpf.org/team_care/. Accessed May 12, 2015.
- Cofer SA (expert opinion). Mayo Clinic, Rochester, Minn. June 8, 2015.
- Hoecker JL (expert opinion). Mayo Clinic, Rochester, Minn. May 20, 2015.