Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. The liver carries out several necessary functions, including detoxifying harmful substances in your body, cleaning your blood and making vital nutrients.
Cirrhosis occurs in response to damage to your liver. Each time your liver is injured, it tries to repair itself. In the process, scar tissue forms. As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function.
Decompensated cirrhosis is the term used to describe the development of specific complications resulting from the changes brought on by cirrhosis. Decompensated cirrhosis is life-threatening.
The liver damage done by cirrhosis generally can't be undone. But if liver cirrhosis is diagnosed early and the cause is treated, further damage can be limited and, rarely, reversed.
Cirrhosis care at Mayo Clinic
Aug. 19, 2017
- Sanchez W, et al. Liver cirrhosis. The American College of Gastroenterology. http://patients.gi.org/topics/liver-cirrhosis. Accessed Dec. 26, 2015.
- Ferri FF. Cirrhosis. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Dec. 26, 2015.
- Cirrhosis. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/liver-disease/cirrhosis/Pages/facts.aspx. Accessed Dec. 27, 2015.
- Boyer TD, et al., eds. Hepatic fibrosis and cirrhosis. In: Zakim & Boyer's Hepatology: A Textbook of Liver Disease. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. https://www.clinicalkey.com. Accessed Dec. 26, 2015.
- Tsochatzis EA, et al. Liver cirrhosis. The Lancet. 2014; 383:1749.
- Feldman M, et al. Overview of Cirrhosis. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed Oct. 8, 2015.
- Singal AK, et al. Model for end-stage liver disease. Journal of Clinical and Experimental Hepatology. 2013;3:50.
- Toshikuni N, et al. Nutrition and exercise in the management of liver cirrhosis. World Journal of Gastroenterology. 2014;20:7286.
- Cook AJ. AllScripts EPSi. Mayo Clinic, Rochester, Minn. Sept. 22, 2015.
- Goldberg E, et al. Cirrhosis in adults: Etiologies, clinical manifestations, and diagnosis. http://www.uptodate.com/home. Accessed Dec. 27, 2015.
- De Robertis R, et al. Noninvasive diagnosis of cirrhosis: A review of different imaging modalities. World Journal of Gastroenterology. 2014;20:7231.
- Czaja AJ. Hepatic inflammation and progressive liver fibrosis in chronic liver disease. World Journal of Gastroenterology. 2014;20:2515.
- Primary biliary cirrhosis (PBC). American Liver Foundation. http://www.liverfoundation.org/abouttheliver/info/pbc/. Accessed Dec. 27, 2015.
- Liver transplant. American Liver Foundation. http://www.liverfoundation.org/abouttheliver/info/transplant/. Accessed Dec. 27, 2015.
- Rakel D. Chronic hepatitis. In: Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Dec. 7, 2015.
- Hepatitis C: A focus on dietary supplements. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/hepatitisc/hepatitiscfacts.htm. Accessed Dec. 27, 2015.
- U.S. News best hospitals 2013-2014. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings/gastroenterology-and-gi-surgery. Accessed Dec. 27, 2015.
- Singh S, et al. Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases: A systematic review and meta-analysis. Clinical Gastroenterology and Hepatology. 2013;11:1573.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. Jan. 10, 2016.
- Keaveny AP (expert opinion). Mayo Clinic, Jacksonville, Fla. March 15, 2016.