Many people with chronic lymphocytic leukemia have no early symptoms. Those who do develop signs and symptoms may experience:
- Enlarged, but painless, lymph nodes
- Pain in the upper left portion of the abdomen, which may be caused by an enlarged spleen
- Night sweats
- Weight loss
- Frequent infections
When to see a doctor
Make an appointment with your doctor if you're concerned about any of your signs and symptoms.
Doctors aren't certain what starts the process that causes chronic lymphocytic leukemia. Doctors know that something happens to cause a genetic mutation in the DNA of blood-producing cells. This mutation causes the blood cells to produce abnormal, ineffective lymphocytes — one type of white blood cell that helps your body fight infection.
Beyond being ineffective, these abnormal lymphocytes continue to live and multiply, when normal lymphocytes would die. The abnormal lymphocytes accumulate in the blood and certain organs, where they cause complications. They may crowd healthy cells out of the bone marrow and interfere with normal blood cell production.
Doctors and researchers are working to understand the exact mechanism that causes chronic lymphocytic leukemia.
Factors that may increase the risk of chronic lymphocytic leukemia include:
- Your age. Most people diagnosed with chronic lymphocytic leukemia are older than 60.
- Your race. Whites are more likely to develop chronic lymphocytic leukemia than are people of other races.
- Family history of blood and bone marrow cancers. A family history of chronic lymphocytic leukemia or other blood and bone marrow cancers may increase your risk.
- Exposure to chemicals. Certain herbicides and insecticides, including Agent Orange used during the Vietnam War, have been linked to an increased risk of chronic lymphocytic leukemia.
Chronic lymphocytic leukemia may cause complications such as:
- Frequent infections. People with chronic lymphocytic leukemia may experience frequent infections. In most cases, these infections are common infections of the upper and lower respiratory tract. But sometimes more-serious infections can develop.
- A switch to a more aggressive form of cancer. A small number of people with chronic lymphocytic leukemia may develop a more aggressive form of cancer called diffuse large B-cell lymphoma. Doctors sometimes refer to this switch as Richter's syndrome.
- Increased risk of other cancers. People with chronic lymphocytic leukemia have an increased risk of other types of cancer, including skin cancer, such as melanoma, and cancers of the lung and the digestive tract.
- Immune system problems. A small number of people with chronic lymphocytic leukemia may develop an immune system problem that causes the disease-fighting cells of the immune system to mistakenly attack the red blood cells or the platelets.
April 19, 2016
- Lichtman MA, et al. Chronic lymphocytic leukemia and related diseases. In: Williams Hematology. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2010. http://www.accessmedicine.com/. Accessed Jan. 22, 2016.
- Niederhuber JE, et al., eds. Chronic lymphocytic leukemia. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014 http://www.clinicalkey.com. Accessed Dec. 22, 2015.
- Chronic lymphocytic leukemia. The Leukemia & Lymphoma Society. https://www.lls.org/sites/default/files/file_assets/cll.pdf. Accessed Feb. 3, 2016.
- Chronic lymphocytic leukemia treatment (PDQ). National Cancer Institute. http://www.cancer.gov/types/leukemia/patient/cll-treatment-pdq. Accessed Jan. 3, 2016.
- When cancer doesn't go away. American Cancer Society. http://www.cancer.org/treatment/survivorshipduringandaftertreatment/when-cancer-doesnt-go-away. Accessed Jan. 3, 2016.
- Berger AM, et al. Cancer-related fatigue, version 2.2015. Journal of the National Comprehensive Cancer Network. 2015;13:1012.
- Shanafelt TD, et al. Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer. 2013;119:363.
- Green tea. Natural Medicines Comprehensive Database. http://naturaldatabase.therapeuticresearch.com/home.aspx. Accessed Feb. 3, 2016.
- D'Arena G, et al. Regulatory T cell modulation by green tea in chronic lymphocytic leukemia. International Journal of Immunopathology and Pharmacology. 2013;26:117.
- Gazya (prescribing information). South San Francisco, Calif.: Genentech, Inc.: 2013. http://www.gazyva.com. Accessed Dec. 22, 2015.
- Imbruvica (prescribing information). Sunnyvale, Calif.: Pharmacyclics, Inc.: 2014. http://www.imbruvica.com. Accessed Dec. 22, 2015.
- Zydelig (prescribing information). Foster City, Calif.: Gilead Sciences, Inc.: 2014. https://www.zydelig.com. Accessed Feb. 4, 2016.
- Revlimid (prescribing information). Summit, NJ: Celgene Corporation: 2015. http://www.revlimid.com. Accessed Feb. 4, 2016.
Chronic lymphocytic leukemia