Chronic granulomatous disease (CGD) is an inherited (genetic) immune system disorder that occurs when a type of white blood cell (phagocyte) that usually helps your body fight infections doesn't work properly. As a result, the phagocytes can't protect your body from bacterial and fungal infections.
People with chronic granulomatous disease often may develop pneumonia, lung infections, skin infections, lymph node infections, liver infections, gastrointestinal inflammation or other infections. They may develop clusters of white blood cells (masses) in infected areas (granulomas). Most people are diagnosed with CGD during childhood, but some people may not be diagnosed until adulthood.
Chronic granulatomous disease care at Mayo Clinic
July 08, 2017
- Rosenzweig SD, et al. Chronic granulomatous disease: Pathogenesis, clinical manifestations, and diagnosis. http://www.uptodate.com/home. Accessed Jan.18, 2017.
- National Library of Medicine. Chronic granulomatous disease. Genetics Home Reference. https://ghr.nlm.nih.gov/condition/chronic-granulomatous-disease?_ga=1.168947753.905232672.1468720729. Accessed Jan. 18, 2017.
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- Rosenzweig SD, et al. Chronic granulomatous disease: Treatment and prognosis. http://www.uptodate.com/home. Accessed Jan. 18, 2017.
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- Brown A. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Dec. 8, 2016.
Chronic granulomatous disease