Chronic granulomatous disease (CGD) is an inherited (genetic) immune system disorder that occurs when a type of white blood cell (phagocyte) that usually helps your body fight infections doesn't work properly. As a result, the phagocytes can't protect your body from bacterial and fungal infections.
People with chronic granulomatous disease often may develop pneumonia, lung infections, skin infections, lymph node infections, liver infections, gastrointestinal inflammation or other infections. They may develop clusters of white blood cells (masses) in infected areas (granulomas). Most people are diagnosed with CGD during childhood, but some people may not be diagnosed until adulthood.
Jan. 09, 2015
- Rosenzweig SD, et al. Chronic granulomatous disease: Pathogenesis, clinical manifestations, and diagnosis. http://www.uptodate.com/home. Accessed Nov. 9, 2014.
- Primary immunodeficiency. Eunice Kennedy Shriver National Institute of Child Health and Human Development. http://www.nichd.nih.gov/publications/pubs/pages/primary_immuno.aspx. Accessed Nov. 9, 2014.
- Jeffrey Modell Centers Network. Primary Immunodeficiency Disorder Resource Network. http://www.info4pi.org. Accessed Nov. 9, 2014.
- Rosenzweig SD, et al. Chronic granulomatous disease: Treatment and prognosis. http://www.uptodate.com/home. Accessed Nov. 9, 2014.
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