CausesBy Mayo Clinic Staff
Scientists don't know exactly what causes chronic fatigue syndrome. It may be a combination of factors that affect people who were born with a predisposition for the disorder.
Some of the factors that have been studied include:
Aug. 30, 2016
Viral infections. Because some people develop chronic fatigue syndrome after having a viral infection, researchers question whether some viruses might trigger the disorder.
Suspicious viruses include Epstein-Barr virus, human herpes virus 6 and mouse leukemia viruses. No conclusive link has yet been found.
- Immune system problems. The immune systems of people who have chronic fatigue syndrome appear to be impaired slightly, but it's unclear if this impairment is enough to actually cause the disorder.
- Hormonal imbalances. People who have chronic fatigue syndrome also sometimes experience abnormal blood levels of hormones produced in the hypothalamus, pituitary glands or adrenal glands. But the significance of these abnormalities is still unknown.
- Chronic fatigue syndrome (CFS). Centers for Disease Control and Prevention. http://www.cdc.gov/cfs/. Accessed March 30, 2014.
- Goldman L, et al. Goldman's Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed March 30, 2014.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed March 30, 2014.
- Gluckman SJ. Clinical features and diagnosis of chronic fatigue syndrome. http://www.uptodate.com/home. Accessed March 30, 2014.
- Chronic fatigue syndrome/myalgic encephalomyelitis. Chicago, Ill.: International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. http://www.iacfsme.org/Portals/0/PDF/PrimerFinal3.pdf. Accessed March 31, 2014.
- Smith MEB, et al. Treatment of myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review for a National Institutes of Health Pathways to Prevention workshop. Annals of Internal Medicine. 2015;162:841.
- Fleming KC (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 22, 2016.