Cervical cancer begins when healthy cells acquire a genetic change (mutation) that causes them to turn into abnormal cells.
Healthy cells grow and multiply at a set rate, eventually dying at a set time. Cancer cells grow and multiply out of control, and they don't die. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can break off from a tumor to spread (metastasize) elsewhere in the body.
It isn't clear what causes cervical cancer, but it's certain that HPV plays a role. HPV is very common, and most women with the virus never develop cervical cancer. This means other factors — such as your environment or your lifestyle choices — also determine whether you'll develop cervical cancer.
Types of cervical cancer
The type of cervical cancer that you have helps determine your prognosis and treatment. The main types of cervical cancer are:
- Squamous cell carcinoma. This type of cervical cancer begins in the thin, flat cells (squamous cells) lining the outer part of the cervix, which projects into the vagina. Most cervical cancers are squamous cell carcinomas.
- Adenocarcinoma. This type of cervical cancer begins in the column-shaped glandular cells that line the cervical canal.
Sometimes, both types of cells are involved in cervical cancer. Very rarely, cancer occurs in other cells in the cervix.
Jan. 31, 2015
- What you need to know about cervical cancer. National Cancer Institute. http://www.cancer.gov/cancertopics/wyntk/cervix. Accessed July 3, 2014.
- Lentz GM, et al. Comprehensive Gynecology. 6th ed. Philadelphia, Pa.: Mosby Elsevier; 2012. http://www.clinicalkey.com. Accessed July 3, 2014.
- Frumovitz M. Invasive cervical cancer: Epidemiology, risk factors, clinical manifestations, and diagnosis. http://www.uptodate.com/home/index.html. Accessed Sept. 30, 2014.
- Niederhuber JE, et al., eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed July 3, 2014.
- Feldman S, et al. Screening for cervical cancer: Rationale and recommendations. http://www.uptodate.com/home/index.html. Accessed Sept. 30, 2014.
- Saslow D, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. American Journal of Clinical Pathology. 2012;137:516.
- De Los Santos JF, et al. Management of early stage cervical cancer. http://www.uptodate.com/home/index.html. Accessed Sept. 30, 2014.
- Cervical cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed July 3, 2014.
- De Los Santos JF, et al. Management of locally advanced cervical cancer. http://www.uptodate.com/home/index.html. Accessed Oct. 1, 2014.
- Genital HPV infection: Fact Sheet. Centers for Disease Control and Prevention. http://www.cdc.gov/std/hpv/stdfact-hpv.htm. Accessed Oct. 20, 2014.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. July 7, 2014.
- Laughlin-Tommaso SK (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 2, 2014.
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