Below are current clinical trials.3 studies in Celiac disease
(open studies only).
Filter this list of studies by location, status and more.
- Celiac disease is a condition where the immune system attacks the cells of the small intestine. The intestine becomes inflamed and cannot digest food properly. The disease most often causes a reaction to foods that contain gluten. Most people can treat celiac disease with a gluten-free diet. However, some people have digestion problems even on a gluten-free diet. Researchers want to try a new antibody therapy for celiac disease. The treatment may block the immune reaction that causes the disease. They will test this antibody in people who have celiac disease that has not responded to a gluten-free diet.
- To see if antibody therapy is a safe and effective treatment for celiac disease that has not responded to standard treatments.
- Individuals at least 18 years of age who have been on a gluten-free diet for 6 to 12 months but still have symptoms of celiac disease.
- Participants will be screened with a physical exam and medical history. Blood samples will be collected. These samples will help determine if the specific antibody treatment is likely to work.
- Before the start of the study, participants will have a biopsy of the small intestine.
- Participants will receive three doses of the study antibody as injections. These doses will be given 3 weeks apart.
- Treatment will be monitored with blood tests and heart function tests. Participants will also have a second small intestine biopsy within a week after the last dose of the antibody.
The purpose of the study is to assess the connection between simvastatin metabolism by an enzyme that varies based on the state of the small intestine in treated celiac disease.
This study will assess the effect of gluten on gut barrier function. Investigators at the Mayo Clinic have developed a new gut permeability test using rhamnose (sugar & water solution), and are hoping to prove its effectiveness in a clinical setting.
Aug. 17, 2016
- Ludvigsson JF, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62:43.
- Ludvigsson JF, et al. Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology. Gut. 2014;63:1210.
- Celiac disease. National Digestive Diseases Information Clearinghouse. http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/celiac-disease/Pages/facts.aspx. Accessed Feb. 5, 2016.
- Ferri FF. Celiac disease. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Feb. 4, 2016.
- Kliegman RM, et al. Disorders of malabsorption. In: Nelson Textbook of Pediatrics. 20th ed. Philadelphia, Pa.: Elsevier; 2016. http://www.clinicalkey.com. Accessed Feb. 4, 2016.
- Green PHR, et al. Celiac disease. Journal of Allergy and Clinical Immunology. 2015;35:1099.
- Feldman M, et al. Celiac disease. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed Feb. 4, 2016.
- Catassi C, et al. World Perspective and Celiac Disease Epidemiology. Digestive Diseases. 2015;33:141.
- Snyder MR, et al. Celiac disease: Advances in diagnosis. Expert Review of Clinical Immunology. 2016;12:449.
- Cook AJ. AllScripts EPSi. Rochester, Minn. Feb. 8, 2016.
- McCarville JL, et al. Pharmacological approaches in celiac disease. Current Opinion in Pharmacology. 2015;25:7.
- U.S. News best hospitals 2015-2016. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings/gastroenterology-and-gi-surgery. Accessed April 6, 2016.
- Barbara Woodward Lips Patient Education Center. Celiac disease. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2007.
- Celiac disease. Natural Medicines. https://naturalmedicines.therapeuticresearch.com/. Accessed April 7, 2016.
- Rishi AR, et al. Refractory celiac disease. Expert Review of Gastroenterology and Hepatology. 2016;10:537.
- AskMayoExpert. Human Leukocyte Antigen Testing (Adult). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016.
- Murray JA (expert opinion). Mayo Clinic, Rochester, Minn. April 21, 2016.