People with unicentric Castleman disease usually do well once the affected lymph node is removed. However, having Castleman disease may increase your risk of lymphoma.
Complications of multicentric Castleman disease can be life-threatening and may include:
- Infection leading to the failure of multiple organs
- Cancer, such as lymphoma or Kaposi's sarcoma
The outlook for people with multicentric Castleman disease varies, depending on the nature of their disease. The presence of HIV/AIDS tends to worsen the outcome.
Research also indicates that people who have multicentric Castleman disease with POEMS syndrome that doesn't involve bone lesions may have worse outcomes, while people who have multicentric Castleman disease with the bone lesion variant of POEMS syndrome tend to do better.
Aug. 27, 2014
- AskMayoExpert. What are the symptoms of Castleman disease? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Brown JR, et al. Unicentric Castleman's disease. http://www.uptodate.com/home. Accessed July 14, 2014.
- Aster JC, et al. Multicentric Castleman's disease. http://www.uptodate.com/home. Accessed July 14, 2014.
- Dispenzieri A, et al. The clinical spectrum of Castleman's disease. American Journal of Hematology. 2012;87:997.
- Fajgenbaum DC, et al. HHV-8-negative, idiopathic multicentric Castleman disease: Novel insights into biology, pathogenesis, and therapy. Blood. 2014;123:2924.
- Robinson D, et al. Clinical epidemiology and treatment patterns of patients with multicentric Castleman disease: Results from two US treatment centers. British Journal of Haematology. 2014;165:39.
- Talat N, et al. Surgery in Castleman's disease: A systematic review of 404 published cases. Annals of Surgery. 2012;255:677.
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