Carotid artery disease occurs when fatty, waxy deposits called plaques clog your carotid arteries. Your carotid arteries are a pair of blood vessels that deliver blood to your brain and head. The buildup of plaques in these arteries blocks the blood supply to your brain and increases your risk of stroke.

Because carotid artery disease develops slowly and often goes unnoticed, the first outward clue that you have the condition may be a stroke or transient ischemic attack (TIA), sometimes referred to as a ministroke.

Treatment of carotid artery disease usually involves a combination of lifestyle changes, medications and, in some cases, surgery or a stenting procedure.

In its early stages, carotid artery disease often doesn't produce any signs or symptoms. You and your doctor may not know you have carotid artery disease until it's serious enough to deprive your brain of blood, causing a stroke or TIA — an early warning sign of a future stroke.

Signs and symptoms of a stroke or TIA may include:

  • Sudden numbness or weakness in the face or limbs, often on only one side of the body
  • Trouble speaking and understanding
  • Sudden trouble seeing in one or both eyes
  • Dizziness or loss of balance
  • A sudden, severe headache with no known cause

When to see a doctor

Talk to your doctor if you have risk factors for carotid artery disease. Your doctor may do some tests to see what shape your arteries are in. Even if you don't have any signs or symptoms, your doctor may recommend aggressive management of your risk factors to protect you from stroke.

Seek emergency care if you experience any of the signs or symptoms of a transient ischemic attack or stroke.

Even if the signs and symptoms last only a short while — usually less than an hour but possibly longer — and then you feel normal, tell your doctor right away. What you may have experienced is a TIA, a temporary shortage of blood flow to a region of your brain. A TIA is an important sign that you're at high risk of having a full-blown stroke, so don't ignore it.

Seeing a doctor early increases your chances that carotid artery disease will be detected and treated before a disabling stroke occurs. It's also possible that a TIA can be due to lack of blood flow in other blood vessels. Your doctor will determine which testing is necessary.

Make sure your close friends and family know the signs and symptoms of stroke and understand that it's critical to act fast in the event of a possible stroke.

Carotid arteries can become stiff and narrow over time due to a gradual accumulation of plaques, which can restrict blood flow and result in carotid artery disease. Plaques consist of clumps of cholesterol, calcium, fibrous tissue and other cellular debris that gather at microscopic injury sites within the artery, creating a blood clot (thrombus). This process is called atherosclerosis.

Normal, healthy carotid arteries — like any other healthy artery — are smooth and flexible and provide a clear pathway for blood flow. If you place a finger under your jawbone on either side of your Adam's apple, you may feel your carotid artery pulse. Your carotid arteries carry oxygen- and nutrient-rich blood to your cerebral cortex and other vital brain structures, which are responsible for your day-to-day functioning.

Factors that stress your arteries and increase the risk of injury, buildup of plaques and disease include the following:

  • High blood pressure. High blood pressure is an important risk factor for carotid artery disease. Excess pressure on the walls of your arteries can weaken them and leave them more vulnerable to damage.
  • Smoking. Nicotine can irritate the inner lining of your arteries. It also increases your heart rate and blood pressure.
  • Age. As you age, your arteries become less elastic and more prone to injury.
  • Abnormal blood-fat levels. High levels of low-density lipoprotein (LDL) cholesterol, the "bad" cholesterol, and high levels of triglycerides, a blood fat, encourage the accumulation of plaques.
  • Diabetes. Diabetes affects not only your ability to handle glucose appropriately but also your ability to process fats efficiently, placing you at greater risk of high blood pressure and atherosclerosis.
  • Obesity. Carrying excess pounds increases your chances of high blood pressure, atherosclerosis and diabetes.
  • Heredity. Having a family history of atherosclerosis or coronary artery disease increases your risk of developing these conditions, as well.
  • Physical inactivity. Lack of exercise contributes to a number of conditions, including high blood pressure, diabetes and obesity.

Often, these risk factors occur together, creating even greater risk than if they occur alone.

The most serious complication of carotid artery disease is stroke. There are different ways carotid artery disease can increase your risk of stroke:

  • Reduced blood flow. A carotid artery may become so narrowed by atherosclerosis that not enough blood is able to reach portions of your brain.
  • Ruptured plaques. A piece of a plaque may break off and flow to smaller arteries in your brain (cerebral arteries). The fragment may get stuck in one of these smaller arteries, creating a blockage that cuts off blood supply to the area of the brain that the cerebral artery serves.
  • Blood clot blockage. Some plaques are prone to cracking and forming irregular surfaces on the artery wall. When this happens, your body reacts as if to an injury and sends platelets — blood cells that help the clotting process — to the area. A large blood clot may develop in this manner and block or slow the flow of blood through a carotid or cerebral artery, causing a stroke.

A stroke can leave you with permanent brain damage and muscle weakness. In severe cases, it can be fatal.

In case of an emergency

Stroke or TIA — often the first indications of carotid artery disease — is an emergency medical condition. If you or a loved one develops signs or symptoms of a possible stroke, call 911 or your local emergency number immediately. Don't attempt to drive yourself to the hospital.

Signs and symptoms to watch for include:

  • Sudden weakness or numbness in the face or limbs, often on only one side of the body
  • The inability to move one or more of your limbs
  • Trouble speaking and understanding
  • Sudden trouble seeing in one or both eyes
  • Dizziness or loss of balance
  • A sudden, severe headache with no known cause

If you have risk factors for carotid artery disease, make an appointment with your doctor. He or she may run tests to evaluate the health of your arteries and may recommend treatments and lifestyle changes to reduce your risk of stroke.

Here's some information to help you get ready for your appointment and what to expect from your doctor.

Information to prepare in advance

  • Write down any symptoms you've experienced, including whether you think you may have had a TIA and when.
  • List your personal risk factors for stroke, including family history of heart disease or stroke and lifestyle habits such as smoking and lack of physical activity.
  • Make a list of your key medical information, including other recent health problems you've had and the names of any prescription and over-the-counter medications you're taking.
  • Find a family member or friend who can come with you to the appointment, and, if possible, someone who may have witnessed your spell. Someone who accompanies you can also help remember what the doctor says.

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment.

What to expect from your doctor

To determine your risk of stroke, your doctor may start by asking questions such as:

  • Have you had any stroke-like symptoms, such as weakness on one side of your body, trouble speaking or sudden vision problems?
  • When did you experience these symptoms? How long did they last?
  • Have you ever seen a doctor for these symptoms?
  • Do you smoke? How much?
  • Do you drink alcohol? How much?
  • Do you exercise regularly?
  • What do you eat in a typical day?
  • Do you have any family history of heart disease or stroke?
  • Have you been diagnosed with any other medical conditions?
  • What over-the-counter and prescription medications are you currently taking?

Next, your doctor may run tests to get a detailed picture of your carotid arteries.

In addition to taking a thorough medical history and recording risk factors and any signs or symptoms, your doctor may conduct or request several tests to evaluate the health of your carotid arteries:

  • Physical examination. Your doctor may hear a "swooshing" sound (bruit) over the carotid artery in your neck, a sound that's characteristic of a narrowed artery. Your doctor may perform a neurological evaluation to test your physical and mental status such as strength, memory and speech capabilities.
  • Ultrasound. A common, noninvasive test used to check for carotid artery disease is a Doppler ultrasound. This variation of the conventional ultrasound assesses blood flow and pressure — and possible narrowing of the blood vessel — by bouncing high-frequency sound waves (ultrasound) off red blood cells.
  • Computerized tomography angiography (CTA). This imaging test uses a contrast dye to highlight your carotid arteries in the pictures taken. The dye is injected into a blood vessel. When it travels to your carotid arteries, a computerized tomography (CT) scan gathers X-ray images of your neck and brain from many angles.
  • Head computerized tomography (CT). This imaging looks at the brain tissue, without giving dye, to rule out bleeding or other abnormalities.
  • Magnetic resonance angiography (MRA). Like CTA, this imaging test uses a contrast (noniodine) dye to highlight the arteries in your neck and brain. A magnetic field and radio waves are used to create cross-sectional, 3-D images.
  • Magnetic resonance imaging (MRI). Like CT, this imaging test looks at the brain tissue for evidence of early stroke or other abnormalities.
  • Cerebral angiogram. A more traditional, and more invasive, imaging procedure called a cerebral angiogram may sometimes be done, but its use is less common as it carries a slight risk of stroke. In this procedure, contrast dye is injected with a catheter that's been threaded directly into your carotid arteries. Detailed X-ray images are then taken.

The goal in treating carotid artery disease is preventing stroke. The method of treatment depends on how narrow your arteries have become.

Mild to moderate blockage

When you have mild to moderate blockage of your arteries, the following recommendations may be sufficient to prevent stroke:

  • Make lifestyle changes. Healthy changes in your behavior can help reduce the stress on your arteries and slow the progression of atherosclerosis. Such changes include quitting smoking, losing weight, eating healthy foods, reducing the amount of salt you eat and exercising regularly.
  • Manage chronic conditions. It's also key to manage any chronic conditions you have, such as high blood pressure, excess weight or diabetes. With your doctor, you can form a plan to specifically address these conditions by managing your blood pressure, maintaining a healthy weight, controlling your blood sugar levels and lowering your cholesterol.
  • Use medications. Your doctor may ask you to take a daily aspirin or another blood-thinning medicine to avoid the formation of dangerous blood clots. He or she may also recommend medications to control your blood pressure, such as angiotensin-converting enzyme (ACE) inhibitors or calcium channel blockers, or a statin medication to lower your cholesterol.

Severe blockage

When you have severe blockage of your arteries — especially if you've already had a TIA or stroke related to the blockage — it's best to open up the artery and remove the blockage. There are two ways to do this:

  • Carotid endarterectomy. This surgical procedure is the most common treatment for severe carotid artery disease. The procedure is done under either local or general anesthesia. After making an incision along the front of your neck, your surgeon opens the affected carotid artery and removes the plaques. The artery is repaired with either stitches or, preferably, a graft. Studies have also shown that the surgery is low risk in most otherwise healthy people, has lasting benefit and helps prevent strokes.
  • Carotid angioplasty and stenting. A carotid endarterectomy isn't recommended when the location of the narrowing or blockage is too difficult for the surgeon to access directly or when you have other health conditions that make surgery too risky. In such cases, your doctor may recommend a procedure called carotid angioplasty and stenting. While you're under local anesthesia, a tiny balloon is threaded by catheter to the area where your carotid artery is clogged. The balloon is inflated to widen the artery, and a small wire mesh coil called a stent is inserted to keep the artery from narrowing again.

Making healthy choices in your daily life can help prevent or slow the progression of carotid artery disease and help prevent the occurrence of a TIA or a stroke. Here are some suggestions:

  • Don't smoke. Stopping smoking reduces stress on your arteries and cuts your risk of a TIA or a stroke. Within a few years of quitting, a former smoker's risk of stroke is similar to a nonsmoker's. It's never too late to quit. It's also never too early.
  • Limit cholesterol and fat. Cutting back on cholesterol and fat, especially saturated fat, in your diet may reduce buildup of plaques in your arteries.
  • Eat a variety of fruits and vegetables. These foods contain such nutrients as potassium, folate and antioxidants, which may protect against a TIA or a stroke.
  • Limit sodium. Avoiding salt may not prevent hypertension, but excess sodium may increase blood pressure in people who are sensitive to sodium. For healthy adults, most experts recommend less than 1,500 milligrams a day of sodium. If you have high blood pressure, keeping to the lower end of the range may help reduce your blood pressure.
  • Exercise regularly. Exercise can lower your blood pressure, increase your level of high-density lipoprotein (HDL) cholesterol — the "good" cholesterol — and improve the overall health of your blood vessels and heart. It also helps you lose weight, control diabetes and reduce stress. If you have high blood pressure, engaging in 30 minutes of moderately vigorous activity (walking or swimming are two examples) on most days of the week is one of the few ways you can lower your pressure without drugs.
  • Limit alcohol. Drink alcohol in moderation, if at all. The recommended limit is no more than one drink daily for women and two a day for men.
  • Maintain a healthy weight. Being overweight contributes to other risk factors, such as high blood pressure, cardiovascular disease and diabetes. Losing weight with diet and exercise may lower your blood pressure and improve your cholesterol levels.
  • Control chronic conditions. You can manage both diabetes and high blood pressure with diet, exercise, weight control and, when necessary, medication. Remember high blood pressure is silent, so know your blood pressure numbers and know your goal blood pressure.
  • Expertise and experience. Mayo Clinic doctors and surgeons evaluate and treat hundreds of people who have carotid artery disease each year, and perform complex surgeries. Mayo Clinic in Arizona, Florida and Minnesota are certified as primary stroke centers by The Joint Commission, a national organization that evaluates and accredits health care providers.
  • Team approach. At Mayo Clinic, doctors trained in heart and blood vessel conditions (cardiologists), blood vessel surgery (vascular and endovascular surgeons), brain conditions (neurologists), brain surgery (neurosurgeons), imaging techniques (radiologists) and other specialties work as a team to diagnose people who have carotid artery disease and determine the most appropriate treatment.
  • Efficient system. Mayo Clinic doctors often can diagnose your condition and develop a treatment plan within a few days.
  • Technology. Mayo Clinic doctors use the most current technology in diagnostic tests and treatment for carotid artery disease.
  • Research. Mayo Clinic doctors actively research new and improved carotid artery disease treatment and conduct clinical trials.

Mayo Clinic in Rochester, Minn., is ranked among the Best Hospitals for neurology and neurosurgery and for heart and heart surgery by U.S. News & World Report. Mayo Clinic also ranks among the Best Children's Hospitals in neurology and neurosurgery and for heart and heart surgery.

At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.

Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.

Why Choose Mayo Clinic

What Sets Mayo Clinic Apart

Mayo Clinic doctors trained in heart and blood vessel disease (cardiologists) and other doctors work together to evaluate your condition. In Mayo Clinic's efficient system, often you may have all your tests and diagnosis within a few days.

To diagnose your condition, your doctor may review your medical and family history and conduct a physical examination. Your doctor may order several tests to diagnose your condition and determine the severity of your condition.

  • Carotid ultrasound. In this test, sound waves create detailed images of the inside of your carotid arteries. This test also shows the structure and blood flow of your carotid arteries.
  • Computerized tomography angiogram (CTA). This test creates a series of X-rays to create detailed, 3-D images of your carotid arteries and your brain. Contrast dye is injected into your blood vessels to make them visible on X-rays.
  • Magnetic resonance angiography (MRA). In this test, magnetic and radio waves create detailed 3-D images of your carotid arteries and your brain. Contrast dye is injected into your blood vessels to make your arteries visible on the images.
  • Carotid angiogram. In this test, doctors insert a thin, flexible tube (catheter) into an artery in your groin and thread it through your blood vessels to your carotid arteries. Contrast dye is then injected into your arteries, which shows the structure and blood flow of your carotid arteries on X-ray images.

Mayo Clinic doctors trained in heart and blood vessel conditions (cardiologists), blood vessel surgery (vascular surgeons), brain conditions (neurologists), brain surgery (neurosurgeons) and other doctors evaluate and treat carotid artery disease. Your treatment team will evaluate you to determine which treatment may be most appropriate for you.

Your treatment may depend on your age, your symptoms, your general health and the severity of your condition. Your doctor will work with you to develop your treatment plan.

  • Carotid angioplasty and stenting. If you have a high surgical risk, doctors may not consider you to be a candidate for surgery. However, you may be a candidate for carotid angioplasty and stenting. In this procedure, you receive local anesthesia, and then your doctor inserts a thin, flexible tube (catheter) with a balloon on the tip in a blood vessel in your neck or groin and threads it to the carotid artery. Your doctor inflates the balloon in the narrowed or blocked artery and inserts a small mesh tube (stent) through the catheter into the opening, to keep your artery from becoming narrowed or blocked after the procedure. You may have less discomfort, smaller incisions and a shorter recovery time in this procedure compared open surgery.
  • Carotid endarterectomy. If you're experiencing symptoms or if you have more than 50 percent blockage in your arteries, your doctor may recommend carotid endarterectomy. In this procedure, you receive local or general anesthesia. Your surgeon makes an incision along the front of your neck, opens your carotid artery and removes the plaques. Your surgeon then repairs the artery with sutures or a graft.
  • Lifestyle changes. If you have mild carotid artery disease or the risk of carotid artery disease, making lifestyle changes may keep your condition from developing or becoming worse. Your doctor will discuss eating a healthy diet, exercising, maintaining a healthy weight and quitting smoking with you.
  • Medications. You may need medications to treat high blood pressure, high blood cholesterol or other conditions. Your doctor may also prescribe aspirin or other anti-clotting medications.
  • Follow-up care. Your doctor will recommend follow-up appointments to monitor your condition.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Doctors trained in cardiovascular diseases, neurology, neurosurgery and interventional neuroradiology evaluate and treat people who have carotid artery disease at Mayo Clinic in Arizona. You may receive care through the Vascular Center.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Doctors trained in cardiovascular diseases, neurology, neurosurgery and radiology (neurological radiology) evaluate and treat people who have carotid artery disease at Mayo Clinic in Florida. You may receive care at the Vascular Center.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Doctors trained in cardiovascular diseases, neurology, neurosurgery, vascular medicine, vascular and endovascular surgery and radiology evaluate and treat people who have carotid artery disease at Mayo Clinic in Minnesota. Staff in the Gonda Vascular Center cares for people who have carotid artery disease and other vascular conditions.

For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.

See information on patient services at the three Mayo Clinic locations, including transportation options and lodging.

Mayo Clinic doctors trained in heart and blood vessel conditions (cardiologists), blood vessel surgery (vascular surgeons), brain and nervous system conditions (neurologists) and other specialties study causes, diagnostic tests, and new and improved treatment options for carotid artery disease.

Mayo Clinic publications

See a list of publications by Mayo Clinic doctors on carotid artery disease on PubMed, a service of the National Library of Medicine.

Read more about Mayo Clinic carotid angioplasty research and the CREST study results regarding carotid endarterectomy and carotid angioplasty.

Oct. 01, 2011