The exact cause of broken heart syndrome is unclear. It's thought that a surge of stress hormones, such as adrenaline, might temporarily damage the hearts of some people. How these hormones might hurt the heart or whether something else is responsible isn't completely clear. A temporary constriction of the large or small arteries of the heart may play a role.
Broken heart syndrome is often preceded by an intense physical or emotional event. Some potential triggers of broken heart syndrome are:
- News of an unexpected death of a loved one
- A frightening medical diagnosis
- Domestic abuse
- Losing a lot of money
- Natural disasters
- A surprise party
- Having to perform publicly
- Job loss
- Physical stressors, such as an asthma attack, a car accident or major surgery
It's also possible that some drugs, rarely, may cause broken heart syndrome by causing a surge of stress hormones. Drugs that may contribute to broken heart syndrome include:
- Epinephrine (EpiPen, EpiPen Jr), which is used to treat severe allergic reactions or a severe asthma attack
- Duloxetine (Cymbalta), a medication given to treat nerve problems in people with diabetes, or as a treatment for depression
- Venlafaxine (Effexor XR), which is a treatment for depression
- Levothyroxine (Synthroid, Levoxyl), a drug given to people whose thyroid glands don't work properly
How is broken heart syndrome different from a heart attack?
Heart attacks are generally caused by a complete or near complete blockage of a heart artery. This blockage is due to a blood clot forming at the site of narrowing from fatty buildup (atherosclerosis) in the wall of the artery. In broken heart syndrome, the heart arteries are not blocked, although blood flow in the arteries of the heart may be reduced.
Mar. 01, 2014
- Reeder GS, et al. Stress-induced (takotsubo) cardiomyopathy. http://www.uptodate.com/home. Accessed Oct. 6, 2013.
- Prasad A, et al. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction. American Heart Journal. 2008;155:408.
- Sharkey SW, et al. Takotsubo (Stress) cardiomyopathy. Circulation. 2011;124:e460.
- Kurisu S, et al. Tako-tsubo cardiomyopathy: Clinical presentation and underlying mechanism. Journal of Cardiology. 2012;60:429.
- Izumi Y. Drug-induced Takotsubo cardiomyopathy. Heart Failure Clinics. 2013;9:225.
- Sharkey SW. Takotsubo cardiomyopathy natural history. Heart Failure Clinics. 2013;9:123.
- Papadakis MA, et al. Current Medical Diagnosis & Treatment 2013. 52nd ed. New York, N.Y.: The McGraw-Hill Companies; 2013. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=1. Accessed Oct. 6, 2013.
- Summers MR, et al. Takotsubo cardiomyopathy definition and clinical profile. Heart Failure Clinics. 2013;9:111.
You Are ... The Campaign for Mayo Clinic
Mayo Clinic is a not-for-profit organization. Make a difference today.