ResearchBy Mayo Clinic Staff
Mayo Clinic doctors trained in brain conditions (neurologists), brain surgery (neurosurgeons), nonsurgical treatments (neurosurgeons and neuroradiologists), brain imaging (neuroradiologists) and others research brain aneurysm development, diagnosis, monitoring, management and treatment.
Researchers study which brain aneurysms need to be treated and which can be monitored. Mayo Clinic researchers also study management of subarachnoid hemorrhages. Learn more about research in neurology and neurosurgery.
Mayo Clinic research of note includes:
Genetic marker. Mayo Clinic researchers discovered evidence of a protein that indicates the presence of a condition (genetic marker) that might help identify brain aneurysms prone to rupture.
They identified three variations (polymorphisms) in a gene that regulates production of endothelial nitric oxide synthase (eNOS), a protein involved in the formation of aneurysms. They found a strong association between the presence of all three variations and a ruptured aneurysm.
ISUIA study. Research led by Mayo Clinic and sponsored by the National Institutes of Health is helping doctors more reliably determine brain aneurysms that need immediate treatment.
The International Study of Unruptured Intracranial Aneurysms (ISUIA) indicated that aneurysm size and location corresponded to the risk of rupture and subarachnoid hemorrhage. Read more about ISUIA in Clinical Update.
Flow diverter research. Mayo Clinic researchers collaborated on the PUFS (Pipeline for Uncoilable or Failed Aneurysms) study and led the ASPIRE (Aneurysm Study of Pipeline in an Observational Registry) study, both of which assessed the feasibility, safety and efficacy of flow diverters for the treatment of unruptured brain aneurysms.
Led by Mayo Clinic and sponsored by Stryker Neurovascular, the SCENT (The Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide Neck Aneurysms) study is a clinical trial to determine the safety and effectiveness of flow diverters in treating larger aneurysms.
Flow diverters are special devices which, when placed across the aneurysm, will redirect flow away from the aneurysm. In the vast majority of patients, placing flow diverters eventually leads to complete obliteration of the aneurysm.
Flow diverters are threaded to the aneurysm site through a catheter placed in the groin area.
- Aneurysm genetics. Mayo Clinic researchers collaborated in the Familial Intracranial Aneurysm Study, which is clarifying the underlying genetic cause for brain aneurysms and frequency of aneurysm detection in the setting of a family history of aneurysm.
- Aspirin study. Data from the International Study of Unruptured Intracranial Aneurysms, led by Mayo Clinic, suggests that people who take aspirin in the setting of an unruptured intracranial aneurysm could possibly be at lower risk of aneurysm rupture. This research is ongoing.
Mayo Clinic publications
See a list of publications on brain aneurysms by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.
Read more about intracranial aneurysm management.
Sept. 01, 2015
- Williams LN, et al. Management of unruptured intracranial aneurysms. Neurology Clinical Practice. 2013;3:99.
- Meyers PM, et al. Indications for the performance of intracranial endovascular neurointerventional procedures: A scientific statement from the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Interdisciplinary Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation. 2009;119:2235.
- Cerebral aneurysm fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/cerebral_aneurysm/detail_cerebral_aneurysm.htm. Accessed March 4, 2014.
- Cerebral aneurysm. American Association of Neurological Surgeons. http://www.aans.org/Patient%20Information/Conditions%20and%20Treatments/Cerebral%20Aneurysm.aspx. Accessed March 4, 2014.
- Daroff RB, et al. Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. https://www.clinicalkey.com. Accessed March 4, 2014.
- Singer RJ, et al. Unruptured intracranial aneurysms. http://www.uptodate.com/home. Accessed March 4, 2014.
- Raper DM, et al. Seizures after aneurysmal subarachnoid hemorrhage: A systematic review of outcomes. World Neurosurgery. 2013;79:682.
- Brown RD (expert opinion). Mayo Clinic, Rochester, Minn. March 9, 2014.
- Brown RD, et al. Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection. Journal of Neurosurgery. 2008;108:1132.
- Hasan DM, et al. Aspirin as a promising agent for decreasing incidence of cerebral aneurysm. Stroke. 2011;42:3156.
- Lanzino G (expert opinion). Mayo Clinic, Rochester, Minn. March 18, 2014.
- Brinjikji W, et al. Endovascular treatment of intracranial aneurysms with flow diverters: A meta-analysis. Stroke. 2013;44:442.
- Brinjikji W, et al. Estimating the proportion of intracranial aneurysms likely to be amenable to treatment with the pipeline embolization device. Journal of Neurointerventional Surgery. 2013;5:45.
- Stryker Neurovascular. Safety and Effectiveness of an Intracranial Aneurysm Embolization System for Treating Large or Giant Wide Neck Aneurysms (SCENT). ClinicalTrials.gov. http://www.clinicaltrials.gov/ct2/show/NCT01716117?term=aneurysm&rank=1. Accessed March 20, 2014.