Behcet's disease symptoms vary from person to person. It may disappear and recur on its own. Symptoms may become less severe over time. Your signs and symptoms depend on which parts of your body are affected.
Areas commonly affected by Behcet's disease include:
- Mouth. Painful mouth sores that look similar to canker sores are the most common sign of Behcet's disease. They begin as raised, round lesions in the mouth that quickly turn into painful ulcers. The sores usually heal in one to three weeks, though they do recur.
- Skin. Skin problems can vary. Some people may develop acne-like sores on their bodies. Others may develop red, raised and tender nodules on their skin, especially on the lower legs.
- Genitals. People with Behcet's disease may develop sores on their genitals. The red, open sores commonly occur on the scrotum or the vulva. The sores are usually painful and may leave scars.
- Eyes. Behcet's disease may cause inflammation in the eye — a condition called uveitis (u-vee-I-tis). Uveitis causes redness, pain and blurred vision in one or both eyes. In people with Behcet's disease, the condition and may come and go.
- Joints. Joint swelling and pain often affect the knees in people with Behcet's disease. The ankles, elbows or wrists also may be involved. Signs and symptoms may last one to three weeks and go away on their own.
- Vascular system. Inflammation in blood vessels (veins and arteries) may occur in Behcet's disease, causing redness, pain, and swelling in the arms or legs when a blood clot results. Inflammation in the large arteries can lead to complications, such as aneurysms and narrowing or blockage of the vessel.
- Digestive system. Behcet's disease may cause a variety of signs and symptoms that affect the digestive system, including abdominal pain, diarrhea and bleeding.
- Brain. Behcet's disease may cause inflammation in the brain and nervous system that leads to headache, fever, disorientation, poor balance or stroke.
When to see a doctor
Make an appointment with your doctor if you notice any unusual signs and symptoms that might indicate Behcet's disease. If you've been diagnosed with Behcet's disease, see your doctor if you notice any new signs and symptoms.
No one knows exactly what causes Behcet's disease. But it may be an autoimmune disorder, which means the body's immune system mistakenly attacks some of its own healthy cells. It's likely that genetic and environmental factors also play a role. Several genes have been found to be associated with the disease. Some researchers believe a virus or bacterium may trigger Behcet's disease in people who have certain genes that make them susceptible to Behcet's.
Factors that may increase your risk of Behcet's include:
- Age. Behcet's disease commonly affects men and women in their 20s and 30s, though children and older adults also can develop the condition.
- Where you live. People from countries in the Middle East and Far East, including Turkey, Iran, Japan and China, are more likely to develop Behcet's.
- Sex. While Behcet's disease occurs in both men and women, the disease is usually more severe in men.
- Genes. Having certain genes is associated with a higher risk of developing Behcet's.
Complications of Behcet's disease depend on your signs and symptoms. For instance, untreated uveitis can lead to decreased vision or even blindness. People with eye signs and symptoms of Behcet's disease need to visit an eye doctor (ophthalmologist) regularly because treatment can help prevent this complication.
Feb. 05, 2016
- Singer OV. Cogan and Behcet's syndromes. Rheumatic Diseases Clinics of North America. 2015;41:75.
- Smith EL, et al. Clinical manifestations and diagnosis of Behcet's syndrome. http://www.update.com/home. Accessed Dec. 20, 2015.
- Smith EL, et al. Pathogenesis of Behcet's syndrome. http://www.update.com/home. Accessed Dec. 20, 2015.
- Smith EL, et al. Treatment of Behcet's syndrome. http://www.update.com/home. Accessed Dec. 20, 2015.
- Alibaz-Oner F, et al. Behcet disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses. Medicine. 2014;94:1.
- Zierhut M, et al. Therapy for ocular Behcet's disease. Ocular Immunology and Inflammation. 2014;22:64.
- Caso F, et al. Biological treatments in Behcet's Disease: Beyond anti-TNF therapy.Mediators of Inflammation. 2014;Article 107421:1.