An atrial septal defect (ASD) is a hole in the wall between the two upper chambers of your heart. The condition is present from birth (congenital). Smaller atrial septal defects may close on their own during infancy or early childhood.

Large and long-standing atrial septal defects can damage your heart and lungs. An adult who has had an undetected atrial septal defect for decades may have a shortened life span from heart failure or high blood pressure in the lungs. Surgery is often necessary to repair atrial septal defects to prevent complications.

Many babies born with atrial septal defects don't have associated signs or symptoms. In adults, signs or symptoms usually begin by age 30, but in some cases signs and symptoms may not occur until decades later.

Atrial septal defect symptoms may include:

  • Heart murmur, a whooshing sound that can be heard through a stethoscope
  • Shortness of breath, especially when exercising
  • Fatigue
  • Swelling of legs, feet or abdomen
  • Heart palpitations or skipped beats
  • Frequent lung infections
  • Stroke
  • Bluish skin color

When to see a doctor

Contact your doctor if you or your child has any of these signs or symptoms:

  • Bluish discoloration of the skin
  • Shortness of breath
  • Tires easily, especially after activity
  • Swelling of legs, feet or abdomen
  • Heart palpitations or skipped beats

These could be symptoms of heart failure or another complication of congenital heart disease.

Doctors know that heart defects present at birth (congenital) arise from errors early in the heart's development, but there's often no clear cause. Genetics and environmental factors may play a role.

An atrial septal defect allows freshly oxygenated blood to flow from the left upper chamber of the heart (left atrium) into the right upper chamber of the heart (right atrium). There, it mixes with deoxygenated blood and is pumped to the lungs, even though it's already refreshed with oxygen. If the atrial septal defect is large, this extra blood volume can overfill the lungs and overwork the heart. If not treated, the right side of the heart eventually enlarges and weakens. In some cases, the blood pressure in your lungs increases as well, leading to pulmonary hypertension.

It's not known why atrial septal defects occur, but congenital heart defects appear to run in families and sometimes occur with other genetic problems, such as Down syndrome. If you have a heart defect, or you have a child with a heart defect, a genetic counselor can estimate the odds that any future children will have one.

When the following conditions occur during pregnancy, they can increase your risk of having a baby with a heart defect:

  • Rubella infection. Becoming infected with rubella (German measles) while pregnant can increase the risk of fetal heart defects.
  • Drug or alcohol use or exposure to certain substances. Use of certain medications, alcohol or drugs, such as cocaine, during pregnancy can harm the developing fetus.

A small atrial septal defect may never cause any problems. Small atrial septal defects often close during infancy.

Larger defects can cause mild to life-threatening problems, including:

  • Right-sided heart failure
  • Heart rhythm abnormalities
  • Shortened life expectancy
  • Increased risk of a stroke

Less common serious complications may include:

  • Pulmonary hypertension. If a large atrial septal defect goes untreated, increased blood flow to your lungs increases the blood pressure in the lung arteries (pulmonary hypertension).
  • Eisenmenger syndrome. In rare cases, pulmonary hypertension can cause permanent lung damage, and it becomes irreversible. This complication, called Eisenmenger syndrome, usually develops over many years and occurs only in a small percentage of people with large atrial septal defects.

Treatment can prevent or help manage many of these complications.

Atrial septal defect and pregnancy

Most women with an atrial septal defect can tolerate pregnancy without any problems. However, having a larger defect or having complications such as heart failure, arrhythmias or pulmonary hypertension can increase your risk of complications during pregnancy. Doctors strongly advise women with Eisenmenger syndrome not to become pregnant because it can endanger the woman's life.

The risk of congenital heart disease is higher for children of parents with congenital heart disease, whether in the father or the mother. Anyone with a congenital heart defect, repaired or not, who is considering starting a family should carefully discuss it beforehand with a doctor. Some medications may need to be stopped or adjusted before you become pregnant because they can cause serious problems for a developing fetus.

An atrial septal defect may first be detected when a suspicious heart murmur is heard during a routine examination. A heart murmur is an abnormal whooshing sound caused by turbulent blood flow. If your doctor suspects an atrial septal defect, you or your child will likely be referred to a doctor who specializes in disorders of the heart (cardiologist).

Because appointments can be brief, and there's often a lot of ground to cover, it's a good idea to arrive well prepared. Here's some information to help you get ready for your appointment, and know what to expect from your doctor.

What you can do

  • Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
  • Write down key personal information, including any major stresses or recent life changes.
  • Make a list of all medications, vitamins or supplements that you're taking.
  • Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together. List your questions from most important to least important in case time runs out. For atrial septal defect, some basic questions to ask your doctor include:

  • What's the most likely cause of my symptoms?
  • Are there other possible causes for my symptoms?
  • What kinds of tests do I need? Do these tests require any special preparation?
  • Is this condition temporary or long lasting?
  • What are my treatment options?
  • What are the risks of cardiac catheterization or surgery?
  • Are there any alternatives to the primary approach that you're suggesting?
  • I have other health conditions. How can I best manage them together?
  • Are there any activity restrictions that I need to follow?
  • Are there any brochures or other printed material that I can take home with me? What websites do you recommend visiting?

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment at any time.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to spend more time on. Your doctor may ask:

  • When did you or your child first begin experiencing symptoms?
  • Have the symptoms been continuous or occasional?
  • Do your symptoms get worse when you exercise?
  • Does anything else seem to make your symptoms worse?
  • Is there anything that seems to improve the symptoms?
  • Do you or does your child have any family history of heart problems?
  • Do you or does your child have any family history of birth defects?

Your doctor may first suspect an atrial septal defect during a regular checkup if he or she hears a heart murmur while listening to your heart using a stethoscope. Or an atrial septal defect may be found when an ultrasound exam of the heart (echocardiogram) is done for another reason.

If your doctor hears a heart murmur or finds other signs or symptoms of a heart defect, he or she may request one or more of the following tests:

  • Echocardiogram. This is a commonly used test to diagnose an atrial septal defect. And some atrial septal defects are found during an echocardiogram done for another reason. In echocardiography, sound waves produce a video image of the heart. It allows your doctor to see your heart's chambers and measure their pumping strength. This test also checks heart valves and looks for any signs of heart defects.
  • Chest X-ray. An X-ray image helps your doctor see the condition of your heart and lungs. An X-ray may identify conditions other than a heart defect that may explain your signs or symptoms.
  • Electrocardiogram (ECG). This test records the electrical activity of your heart and helps identify heart rhythm problems.
  • Cardiac catheterization. In this test, a thin, flexible tube (catheter) is inserted into a blood vessel at the groin or arm and guided to your heart. Through catheterization, doctors can diagnose congenital heart defects, test how well your heart is pumping and check the function of your heart valves. Using catheterization, the blood pressure in your lungs also can be measured. Doctors are investigating catheterization techniques to repair heart defects as well.
  • Magnetic resonance imaging (MRI). MRI is a technique that uses a magnetic field and radio waves to create 3-D images of your heart and other organs and tissues within your body. Your doctor may request an MRI if echocardiography can't definitively diagnose an atrial septal defect.
  • Pulse oximetry. This painless test measures how well oxygen is reaching your tissues. It helps detect whether oxygenated blood is mixing with deoxygenated blood, which can help diagnose the type of heart defect present. A small clip on your fingertip measures the amount of oxygen in your blood.

If your child has an atrial septal defect, your doctor may recommend monitoring it for a period of time to see if it closes on its own, while treating any symptoms with medications. Many atrial septal defects close on their own during childhood. For those that don't close, some small atrial septal defects don't cause any problems and may not require any treatment. But many persistent atrial septal defects eventually require surgery to be corrected.

If your child needs treatment, the timing of it depends on your child's condition and whether your child has any other congenital heart defects.


Medications won't repair the hole, but they may be used to reduce some of the signs and symptoms that can accompany an atrial septal defect. Drugs may also be used to reduce the risk of complications after surgery. Medications may include those to:

  • Keep the heartbeat regular. Examples include beta blockers (Lopressor, Inderal) and digoxin (Lanoxin).
  • Reduce the risk of blood clots. Anticoagulants, often called blood thinners, can help reduce the chances of developing a blood clot and having a stroke. Anticoagulants include warfarin (Coumadin) and anti-platelet agents, such as aspirin.


Many doctors recommend repairing an atrial septal defect diagnosed during childhood to prevent complications as an adult. For adults and children, surgery involves plugging or patching the abnormal opening between the atria. Doctors can do this through two methods:

  • Cardiac catheterization. A thin tube (catheter) is inserted into a blood vessel in the groin and guided to the heart. Through the catheter, a mesh patch or plug is put into place to close the hole. The heart tissue grows around the mesh, permanently sealing the hole.
  • Open-heart surgery. This type of surgery is done under general anesthesia and requires the use of a heart-lung machine. Through an incision in the chest, surgeons use patches or stitches to close the hole.

Medical monitoring

Follow-up care depends on the type of defect and whether other defects are present. For simple atrial septal defects closed during childhood, only occasional follow-up care is needed. For adults, follow-up care may depend on any resulting complications.

If you find out you have a congenital heart defect, or you've had surgery to correct one, you may wonder about limitations on activities and other issues.

  • Exercise. Having an atrial septal defect usually doesn't restrict you from activities or exercise. If you have complications, such as heart failure or pulmonary hypertension, you may not be able to do some activities or exercises. Your cardiologist can help you learn what is safe.
  • Diet. A heart-healthy diet based on fruits, vegetables and whole grains — and low in saturated fat, cholesterol and sodium — can help you keep your heart healthy. Eating one or two servings of fish a week also is beneficial.
  • Preventing infection. Some heart defects, and the repair of defects, create changes to the surface of the heart in which bacteria can become stuck and grow into an infection (infective endocarditis). Atrial septal defects generally aren't associated with infective endocarditis. But if you have other heart defects in addition to an atrial septal defect, or if you've recently had atrial septal defect repair, you may need to take antibiotics before certain dental or surgical procedures.

In most cases, atrial septal defects can't be prevented. If you're planning to become pregnant, schedule a preconception visit with your health care provider. This visit should include:

  • Getting tested for immunity to rubella. If you're not immune, you should be vaccinated.
  • Going over your current health conditions and medications. You'll need to carefully monitor certain health problems during pregnancy. Your doctor also may recommend adjusting or stopping certain medications before you become pregnant.
  • Reviewing your family medical history. If you have a family history of heart defects or other genetic disorders, consider talking with a genetic counselor to determine what the risk might be before getting pregnant.
  • Experience. Mayo Clinic doctors trained in heart disease (cardiologists), doctors trained in treating children who have heart disease (pediatric cardiologists), doctors trained in heart surgery (cardiovascular surgeons) and others have many years of experience evaluating and treating adults and children who have atrial septal defects and other congenital heart diseases.
  • Team approach. Mayo Clinic doctors work together to diagnose and treat your condition.
  • Diagnostic tests. Mayo Clinic doctors diagnose atrial septal defect and other congenital heart diseases with several tests, including echocardiogram, electrocardiogram, cardiac catheterization and other tests.
  • Treatment expertise. Mayo Clinic doctors have expertise treating atrial septal defects with many options. Doctors perform a percutaneous device closure procedure when possible. In this procedure, doctors insert a small tube (catheter) into an artery in your groin and thread it to your heart, and insert a closure device into the hole in the septum through the catheter. Doctors also may perform open-heart surgery or minimally invasive heart surgery, which involves smaller incisions that may heal quicker and result in less discomfort than the larger incision usually made in open-heart surgery. Surgeons perform many surgeries to treat atrial septal defects each year.
  • Congenital heart disease treatment. Mayo Clinic cardiologists and others have experience treating congenital heart diseases, including atrial septal defects. Staff in the Center for Congenital Heart Disease at Mayo Clinic in Minnesota treats adults and children who have congenital heart disease.
  • Research. Mayo Clinic doctors study potential diagnostic tests and treatments for atrial septal defect and other congenital heart diseases and conduct clinical trials.

Mayo Clinic in Rochester, Minn., is ranked among the Best Hospitals for heart and heart surgery and for rehabilitation by U.S. News & World Report.

At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.

Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.

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What Sets Mayo Clinic Apart

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Doctors trained in cardiovascular diseases and cardiovascular and thoracic surgery treat adults who have atrial septal defects at Mayo Clinic in Arizona.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Doctors trained in cardiovascular diseases and cardiothoracic surgery treat adults who have atrial septal defects at Mayo Clinic in Florida.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Doctors trained in pediatric cardiology, cardiovascular diseases, cardiovascular surgery and other areas treat adults and children who have atrial septal defects at Mayo Clinic in Minnesota. Doctors in the Center for Congenital Heart Disease manage all aspects of complex congenital heart disease.

For appointments or more information, call Cardiovascular Diseases at 507-284-3994 8 a.m. to 5 p.m. Central time, Monday through Friday or complete an online appointment request form.

Doctors trained in treating children who have heart disease (pediatric cardiologists) and doctors trained in heart surgery (cardiovascular surgeons) treat children who have atrial septal defects and other congenital heart diseases at Mayo Clinic in Minnesota.

A team of specialists from the Center for Congenital Heart Disease will coordinate your child's care. Children needing hospitalization receive care at Mayo Eugenio Litta Children's Hospital at Mayo Clinic in Minnesota.

For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.

See information on patient services at the three Mayo Clinic locations, including transportation options and lodging.

Mayo Clinic doctors trained in heart disease (cardiologists) and heart surgery (cardiovascular surgeons) actively research new diagnostic procedures and treatment options for people who have atrial septal defects and other congenital heart diseases. Learn more on the cardiovascular diseases research website.


Read publications by Mayo Clinic authors at PubMed, a service of the National Library of Medicine.

Dec. 14, 2011