Characteristic Angelman syndrome signs and symptoms include:
- Developmental delays, such as lack of crawling or babbling at 6 to 12 months, and intellectual disability
- Lack of or minimal speech
- Inability to walk, move or balance well (ataxia)
- Frequent smiling and laughter
- Happy, excitable personality
People who have Angelman syndrome may also have other signs and symptoms, including:
- Seizures, usually beginning between 2 and 3 years of age
- Stiff or jerky movements
- Small head size, with flatness in the back of the head (microbrachycephaly)
- Tongue thrusting
- Light pigmentation in hair, skin and eyes (hypopigmentation)
- Unusual behaviors, such as hand flapping and arms uplifted while walking
When to see a doctor
Most babies with Angelman syndrome don't show signs or symptoms of the disorder when they're born. The first signs of Angelman syndrome are usually developmental delays, such as lack of crawling or babbling, between 6 and 12 months.
If your child seems to have developmental delays or if your child has other signs or symptoms of Angelman syndrome, make an appointment with your child's doctor.
Dec. 05, 2014
- NINDS Angelman syndrome information page. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/angelman/angelman.htm. Accessed Oct. 6, 2014.
- Angelman syndrome. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/angelman-syndrome. Accessed Oct. 6, 2014.
- Angelman syndrome diagnostic criteria. Angelman Syndrome Foundation. http://www.angelman.org/understanding-as/medical-info/diagnostic-criteria/. Accessed Oct. 6, 2014.
- Angelman syndrome diagnostic testing. Angelman Syndrome Foundation. http://www.angelman.org/understanding-as/medical-info/diagnostic-testing/. Accessed Oct. 6, 2014.
- Bailus BJ, et al. The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders. BMC Neuroscience. 2014;15:76.