Amyloidosis is often overlooked because the signs and symptoms can mimic those of more-common diseases. Diagnosis as early as possible can help prevent further organ damage. Precise diagnosis is important because treatment varies greatly, depending on your specific condition.
Your doctor is likely to start with a thorough medical history and physical exam. After that, you may have:
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- Laboratory tests. Your blood and urine may be analyzed for abnormal protein that can indicate amyloidosis. Depending on your signs and symptoms, you may also have thyroid and liver function tests.
- Biopsy. A tissue sample may be taken and checked for signs of amyloidosis. The biopsy may be taken from your abdominal fat, bone marrow, or an organ such as your liver or kidney. Tissue analysis can help determine the type of amyloid deposit.
- Imaging tests. Images of the organs affected by amyloidosis can help establish the extent of your disease. Echocardiogram may be used to assess the size and functioning of your heart. Other imaging tests can evaluate the extent of amyloidosis in your liver or spleen.
- Gorevic PD. An overview of amyloidsosis. http://www.uptodate.com/home. Accessed May 4, 2014.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed May 4, 2014.
- AskMayoExpert. When should light chain amyloidosis be suspected? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Rajkumar SV. Clinical presentation, laboratory manifestations and diagnosis of immunoglobulin light chain (AL) amyloidosis (primary amyloidosis). http://www.uptodate.com/home. Accessed May 4, 2014.
- Gorevic PD. Causes and diagnosis of secondary (AA) amyloidosis and relation to rheumatic diseases. http://www.uptodate.com/home. Accessed May 4, 2014.
- Hoffman R, et al. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed May 5, 2014.
- Gertz MA. Immunoglobulin light chain amyloidosis: 2013 update on diagnosis, prognosis, and treatment. American Journal of Hematology. 2013;88:417.
- Dispenzieri A, et al. What do I need to know about immunoglobulin light chain (AL) amyloidosis? Blood Reviews. 2012;26:137.
- Vrana JA, et al. Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics. Haematologica. In press. Accessed May 5, 2014.
- Warsame R, et al. Outcomes and treatments of patients with immunoglobulin light chain amyloidosis who progress or relapse postautologous stem cell transplant. European Journal of Haematology. In press. Accessed May 5, 2014.
- Dispenzieri A, et al. High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis. Heart. 2014;100:383.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. May 8, 2014.
- Gorevic PD. Genetic factors in the amyloid diseases. http://www.uptodate.com/home. Accessed June 11, 2014.