Signs and symptoms of amyloidosis depend on which of your organs are affected. When signs and symptoms are evident, they may include:

    • Swelling of your ankles and legs
    • Weakness
    • Significant weight loss
    • Shortness of breath
    • Numbness or tingling in your hands or feet
    • Diarrhea or constipation
    • Feeling full quickly
    • Severe fatigue
    • An enlarged tongue (macroglossia)
    • Skin changes, such as thickening or easy bruising
    • Purplish patches (purpura) around the eyes
    • An irregular heartbeat
    • Difficulty swallowing
    • Protein in the urine (detected by urine tests)

    When to see a doctor

    If you persistently experience any of the signs or symptoms that may be associated with amyloidosis, see your doctor to determine whether the underlying cause may be amyloidosis or another problem.

    Aug. 06, 2011

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