The potential complications of amyloidosis depend on which organs the amyloid deposits affect. Amyloidosis can seriously damage your:
July 09, 2015
- Kidneys. Amyloid can harm the kidneys' filtering system, causing protein to leak from your blood into your urine. The kidneys' ability to remove waste products from your body is lowered, which may eventually lead to kidney failure.
- Heart. Amyloid reduces your heart's ability to fill with blood between heartbeats. Less blood is pumped with each beat, and you may experience shortness of breath. If amyloidosis affects your heart's electrical system, your heart rhythm may be disturbed.
- Nervous system. You may experience pain, numbness or tingling of the fingers or numbness, lack of feeling or a burning sensation in your toes or the soles of your feet. If amyloid affects the nerves that control your bowel function, you may experience periods of alternating constipation and diarrhea. Sometimes amyloidosis affects nerves that control blood pressure, and you may experience dizziness or near fainting when standing too quickly, as a result of a drop in your blood pressure.
- Gorevic PD. An overview of amyloidsosis. http://www.uptodate.com/home. Accessed May 4, 2014.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed May 4, 2014.
- AskMayoExpert. When should light chain amyloidosis be suspected? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Rajkumar SV. Clinical presentation, laboratory manifestations and diagnosis of immunoglobulin light chain (AL) amyloidosis (primary amyloidosis). http://www.uptodate.com/home. Accessed May 4, 2014.
- Gorevic PD. Causes and diagnosis of secondary (AA) amyloidosis and relation to rheumatic diseases. http://www.uptodate.com/home. Accessed May 4, 2014.
- Hoffman R, et al. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed May 5, 2014.
- Gertz MA. Immunoglobulin light chain amyloidosis: 2013 update on diagnosis, prognosis, and treatment. American Journal of Hematology. 2013;88:417.
- Dispenzieri A, et al. What do I need to know about immunoglobulin light chain (AL) amyloidosis? Blood Reviews. 2012;26:137.
- Vrana JA, et al. Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics. Haematologica. In press. Accessed May 5, 2014.
- Warsame R, et al. Outcomes and treatments of patients with immunoglobulin light chain amyloidosis who progress or relapse postautologous stem cell transplant. European Journal of Haematology. In press. Accessed May 5, 2014.
- Dispenzieri A, et al. High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis. Heart. 2014;100:383.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. May 8, 2014.
- Gorevic PD. Genetic factors in the amyloid diseases. http://www.uptodate.com/home. Accessed June 11, 2014.