Quality CareFind out why Mayo Clinic is the right place for your health care. Make an appointment.
Meet the StaffFind a directory of doctors and departments at all Mayo Clinic campuses. Visit now.
Research and Clinical TrialsSee how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care. Explore now.
Visit Our SchoolsEducators at Mayo Clinic train tomorrow’s leaders to deliver compassionate, high-value, safe patient care. Choose a degree.
Professional ServicesExplore Mayo Clinic’s many resources and see jobs available for medical professionals. Get updates.
Give to Mayo ClinicHelp set a new world standard in care for people everywhere. Give now.
Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.
Subscribe to Housecall
Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
Subscribe to our Alzheimer's Caregiving e-newsletter to stay up to date on Alzheimer's topics.
Recently one of you wrote: "A cure has been found according to several Internet sites — supposedly mice have been cured so people are next, or so they say. Is this just a joke on we who desperately await the cure?"
I often receive inquiries similar to the one above from families affected by Alzheimer's who have heard or read about an "Alzheimer's cure." Time and time again, I'm saddened by these "stories" that build unrealistic expectations for families who desperately await a cure.
It's important to realize that research being done on mice creates only possibilities in humans — although vital to research, animal research is only a first step. It's important to realize that that mice and humans simply don't suffer from the same illnesses, including Alzheimer's disease.
Mice used in Alzheimer's related studies are genetically altered to display signs of Alzheimer's disease, but they don't have the disease the same way humans do. In fact, there've been many promising studies in animal models that once conducted in human clinical trails turn out to either not work or to have unexpected toxicity.
A cure or treatment for Alzheimer's disease that works in mice has no immediate application to humans, and any potential benefit would be years away. As with most things you read on the Internet or elsewhere, if it sounds too good to be true, it probably is.
Selecting "Submit" signifies that you have read and agree to our posting guidelines.
As long as the medical and pharmaceutical costs in this country skyrocket so high that peoples medical bills aren't payable,how can we even hope to find cures for a disease, any disease? In fact, the medical model is part of the disease process itself. I'm beginning to think the poor people in the highlands of Ikaria Greece have the right idea. Clean non toxic water, air, and self raised food and surrounded by people whose lives aren't so complicated and toxic that they can actually have the energy to care, about anything, themselves, each other, life, etc. We are running around in this country trying to figure out how to feed the increasing numbers of homeless people, while all being one step away from being homeless ourselves... crazy stuff. Here have some more anxiety medications this pharmaceutical company invented and will make millions off of, because your society we collectively created is whacked. Go Blue Zone project! I love the comment about playing pool! That is hopeful. Play more, play games, socialize. Go right tribe!
Does curry powder help people with dementia?
I heard from very reliable sources that a "cure" would be introduced and available this year?!?!?!
We were told our Mother had Alzheimer's by several medical MD's in 2002 and was declining rapidly. They gave her only one year. She had a professional pool playing friend and he started teaching her his own way that included 'NO DRUGS'! She had never played pool before in her life. Her late husband was a MD doctor, so they were golfer's. Lo and behold, she improved greatly!!! This is eleven years later and she still maintains independent living at the age of 85 years old. Her professional pool playing friend said he never knew anyone in his profession that ever was inflicted with Alzheimer's. Will the medical profession precribe this treatment,,, NO,,, for there is no money in it for them and they do not know what this man know's; nor will they seek or ask! This is not hype, but a true story that we view as a great blessing for our family!!
All I'm reading here is about meds. I live in Canada (I lived in the U.S. the first 35 years of my life) and am now 76. Meds aren't pushed as much here - thank goodness!! I'm attending a Brain Fit class and find it really helping with poor memory, etc. This class teaches Cognitive Coaching (Cognitive Fit Minds(tm)InterActive Program). Programs like this should be available to more Seniors I know there is perhaps a genetic link but this IS making a difference.
what about the human subjects and insulin injections
My name is Rick Phelps. I am Founder of Memory People™, the largest Support Group site on FB that deals with Support.
We have over 1600 Members from all over the world. What makes us different from other sites, is what is in this article.
We do not talk of Cures, or the latest concoction someone reads on the internet. We want a Cure, of course, its just not we do. We offer Support. Its what we do, its all we do. We leave the Cure thing, the donation thing, the false hope to other sites.
Alzheimer Sites on the internet are a dime a dozen. We deal in Support only. We have Patients, Caregivers, Family Members and Advocates. All with the same thing in common. All needing Support. We offer more Support than some Family members do, we are very aware of the Denial that comes with this disease. We no not condone Denial, but we realize it happens. We listen together, we laugh, we cry...We are Family. Please join us on Memory People™. We are changing lives, one person at a time...
Give it a chance. for pity sakes. I have solved problems for 35 years in the Nuclear Industry and I firmly believe there is a solution to every problem mankind has to face. Do clinical testing ASAP on Alzheimer's patients in ALL of it's stages to get solid proof one way or the other.
The Insulin Nasal Spray looks good as a cure.
My husband was diagnosed with AD in 2003.The Research Center at our Hospital developed a State of Art Machine which tracks markers in the Brain that show the progession of AD. He was in the beginning state. Last year he had another test which showed him in the middle stage.My Mother had AD, so I have had a lot of experience with being a AD Care Giver. Since my husband was diagnosed I have done everything possible to delay the Disease until there is a Drug which will stop or reverse AD. I have the benefit of having a Doctor who has run some of the AD Trials and is Up-to-Date on the latest Research.
My husband's program: 1. Meds: Combination Therapy with Aricept and Namenda. A year ago he started Axona and I removed sugar from his diet except for fruit. I saw a difference one month after the Axona. He stopped having bad dreams at night, we both got a good night's sleep. During the past 6 months he started getting a little aggressive and continued the very slow decline that he has had for 9 years.I took him again to his Dr.to see if there was anything else that could be done. He wrote a Off-Label Prescription for 500 mg Depakote at bedtime to see if it might make a difference. It is a Anti-siezure drug. A Trial just started with AD patients. On the 3rd day my husband could shave, operate the shower,no agression .His Blood Work is 100% normal now. Also does Walks and Gym 4/wk.
I feel he is doing very good considering it is now 9 years!
Previous comment on heavy metals.
Certain metal compounds such as mercury chloride, methyl mercury, and aluminum fluoride can activate phospholipase C--an enzyme that may trigger late onset Alzheimer's disease. This enzyme exports zinc which contributes to high homocysteine levels which in turn leads to high levels of peroxynitrites. Other factors which contribute to high levels of peroxynitrites are high glucose levels, high blood pressure, the Apoe4 gene, presenilin gene mutations, bisphosphonate osteoporosis drugs, and late estrogen replacement therapy (the last two factors may help explain why women are more at risk for getting Alzheimer's disease than men). At least some metal compounds then may increase the risk for Alzheimer's disease.
I was taught the heavy metals in the brain causes Alzheimer's ? If anyone else know's any info about the heavy metals, please do post a comment pertaining to this.
Several small-scale clinical trials have concluded that aromatherapy could well be an effective treatment for Alzheimer's disease. These trials along with case studies indicate the following improvements in Alzheimer's patients who receive aromatherapy: improved sleep, better mood, better ability to communicate, greater awareness, and increased alertness. I have observed all of these changes in my own mother, whom has been on aromatherapy for three years. The best essential oils for the treatment of the disease are those high in polyphenols, such as cloves, cinnamon leaf, red thyme, bay leaf, rosemary, and sage.
Aromatherapy scavenges peroxynitrites which are the main cause of memory impairment, disturbed sleep, depression, lethargy, and impaired sense of smell in Alzheimer's disease. They also reverse the oxidation of a variety of receptors, transport systems, and enzymes including those involved in the uptake of choline and in the prodcution of acetylcholine--the main compound invovled in memory retrieveal. Indeed, the initial clinical trials, case studies, and research evidence all strongly point in the direction of aromatherapy as an effective treatment of Alzheimer's disease. I urge the medical community to examine this potential breakthrough carefully and soon.
That is really devastating when people write that there has been a 'cure' for alzheimer's when that seems to be quite a way in the future.
It sure would be nice to have someone write about what actually does help the Alzheimers patient.
My echo cardiogram showed 'Inferior wall Ischaemia( Intraseptal), but Cardiac catheterisation did not show any blockage in either coronaries. I am being treated as a heart patient and am on Isosorbide daily with nitroglycerine on only PRN basis. I heard there could be some sophisticated test. I want/need to know. Thank you.
My wife's AD is probably at Mid-stage, still able to care for herself. I intend to try to keep her at home as long as possible, but I have begun checking out Assisted-living establishments, for what seems to be the inevitable. The first two places were new, high-end, and very much out of my league. I understand that Medicare doesn't pay for this, but what I'm not clear on, is how the Medicaid process works. I understand we would have to spend down her portion of our savings, which would leave me with some of the savings. I wonder if someone could explain the process to me, so that when I do see an attorney I understand what we are getting into. Appreciate any assistance. Thank you
About once a month my brother calls to tell me about some drug he saw on TV he thinks my 84 year old dad needs. I feel like a bad person, but I don't want Pa taking a bunch of drugs, especially since most of them have terrible side effects. Pa's doctor agrees with me so far. Am I so wrong letting this disease run its course so long as the doctor says okay?
Has anyone had experience with the brain exercise program being offered by christiangoodman.com, which promotes breathing and brain exercises to supply more oxygen to the brain?
My wife was diagnosed as having dementia associated with parkinsons disease first in 2003 at the age of 64,and was given Parkinsons medication to no effect or improvement. The specialists then decided she had AD.She was given the drugs mentioned in the article.All her symptoms got worse and she had every side effect possible and her attitude and behaviour got so bad that she was admitted to a psychiatric geriatric hospital when I could not cope any longer.The hospital stopped the AD drugs,but the damage done was irreversible.After 3 months in the hospital she was diagnosed as having Lewy body dementia.Some of the doctors agree that the AD drugs would have speeded up her decline.She is now in a dementia care home and is a complete physical and mental wreck.My contention is that the prescibing of these drugs should only be done with the utmost care and the medical professionals should never,ever, assume anything without due care and attention.
Cerebrolysin....Only America doesn't use it. Works fabulously. Look it up in PubMed! It's been around since the 1990's.
I am 64 with some form of dementia. I care for my 85yr old mother with dementia. I am fatigued trying to fight my way through all the things necessary to live with this disease. I feel my deterioration has sped up greatly. The only hope I have is that a cure is found before I end up in a care home. I believe even if they did find a cure, it would take years to reach those of us that need it.
Janet, to answer you question. Yes, we are so desperate for any cure.
I was recently (3 months ago) diagnosed with AD. It was creeping up on me and I had discussed it with my physician. I requested a PET Scan. Its report uses words such as mild & moderate. I searched for clues for a cure for 10 yrs while I cared for my mother and watched others in her family deteriorate with AD.
Sans a cure, I'm trying to alleviate my fears of who is going to care for me--now I care for my 82 yr-old-significant other with Melanoma and make medical decisions for him--my daughters watched my mother fade, but they have no concept of what it will actually do to them when they can no longer depend on me.
I will be 75 soon and have a book publishing business with a friend who is 83--started last year. I still edit books, more carefully now, and hired my grandson, a budding writer and editor, to help and double check some of my work. I hired his older sister to organize my office, learn about the financial aspects of the business, learn to do my checkbooks, invoicing and many things I will be unable to handle soon. I pay my daughter to clean my house (she's widowed and no income) to get her used to helping me out.
Why am I doing this & telling you about it? Because I can. I can do many things. I refuse to be a victim or just a number until I no longer have any control. I want to work. I will as long as I can. Perhaps there will be no cure but we can make happy memories for them & even a little money. This is how I want to be remembered --not as a ve
I wonder if some of the people in nursing homes don't really HAVE dementia or Alzheimer's....I know of at least 3 people (one being my father) who showed symptoms which would seem to be one of those...when actually what was going on was that they had a Urinary Tract Infection.....which puts bacteria in your system. Which does a huge number on your body PLUS your mind. My father was 89, had other health concerns and died. One of the others was given antibiotics and was back to her normal self after about 3 days.
My spouse has Alzheimers, and I don't care what they experiment on, as long as they can find something before he reaches the point of not knowing who I am.
He has been on Aricept since 2000, and just recently increased the dosage from 5 mg to 10 mg. Please let someone soon come up with something even better than Aricept. If you are not a caretaker, then don't bother to reply.
who is Dr. Susan Gudakunst claims several cures
My husband was on Aricept-didn't do anything except subject him to hallucinations. In addition, he was put on the latest one-don't remember the name, but it had gotten raves in Germany. Again, absolutely no help. His Doctor commented on the use of mice and said pigs should be used for testing because their body makeup is closest to humans.
So this raises the question in my mind - why are we using mice to conduct these experiments?? I am not a huge lover of mice (especially in my house), but why are we experimenting on them if the end result of the study doesn't have any application to humans? Are we so desperate for any cure? Is the chase for grant money so desperate & competitive that studies are designed with mice just to get the grant dollars? This seems quite puzzling & unkind to me.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not for profit mission.
Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.